ArticleBMC geriatrics2023
Preoperative cerebrospinal fluid biomarkers may be associated with postoperative delirium in patients undergoing knee/hip arthroplasty: the PNDABLE study.
Article in BMC geriatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Gut microbiota and blood biomarkers as correlating factors in patients with postoperative delirium: analysis of three prospective observational studies.Molecular psychiatry · 2026Article
- Association of mild cognitive impairment and comorbid depression with postoperative delirium in patients undergoing knee/hip arthroplasty: a prospective cohort study.Frontiers in medicine · 2026Article
- Relationship between the preoperative AST/ALT ratio and postoperative delirium and 3-year mortality in patients undergoing total knee or hip arthroplasty: a prospective cohort study.International journal of surgery (London, England) · 2025Article
- Potential Risk to Brain Health after Surgical Interventions: Biomarkers to Predict the Occurrence of Cognitive Decline.Aging and disease · 2025Review
- Potential associated factors of postoperative neurocognitive dysfunction in elderly patients: precursor of BDNF and mature BDNF in serum.Aging clinical and experimental research · 2025Article
- Association of cardiometabolic multimorbidity with postoperative delirium and three-year mortality in patients undergoing knee/hip arthroplasty: a prospective cohort study.International journal of surgery (London, England) · 2025Article
- Emerging biomarkers of postoperative delirium at the intersection of neuroinflammation and neurodegeneration.Frontiers in aging neuroscience · 2025Review
- Circulating tsRNAs serve as potential biomarkers for predicting postoperative delirium in elderly patients receiving lower extremity orthopedic surgery.Frontiers in psychiatry · 2025Article
- Physical activity may a probably protective factor for postoperative delirium: the PNDABLE study.Frontiers in aging neuroscience · 2024Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn the global aging population, the incidence of postoperative delirium (POD) is increasing. Therefore, finding its effective predictive tools becomes crucial. We aimed to identify potential Cerebrospinal fluid (CSF)biomarkers for POD.
methodsA total of 825 patients undergoing knee/hip arthroplasty under combined spinal-epidural anesthesia were selected. The patients were aged 40 to 90 years with American Society of Anesthesiologists physical status I~II. The Mini-Mental State Examination was completed 1 day before the operation. CSF was extracted after successful spinal-epidural combined puncture, and α-synuclein (α-syn), amyloid beta
resultsA total of 92 patients developed POD and the incidence of POD was 11.15%. The results of the multivariable logistic regression showed that CSF t-Tau (P = 0.004, OR = 1.006, 95%CI 1.002~1.009) and α-syn (P = 0.004, OR = 1.001, 95%CI 1.000~1.001) were positively associated with the occurrence rate of POD, while Aβ
conclusionsCSF Aβ
trial registrationClinical Registration No. ChiCTR2000033439.
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