Evidence map›Paper›PMID 37165200›Full record

ArticleBritish journal of cancer2023

Maternal and childhood medical history and the risk of childhood brain tumours: a case-control study in Ontario, Canada.

Sierra Cheng, John R McLaughlin, M Catherine Brown, Hamad Al-Sawaihey, James Rutka, Eric Bouffet, Cynthia Hawkins, A Elizabeth Cairney, Adrianna Ranger, Adam J Fleming and 4 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 1 country.

Sierra ChengProsserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, ON, Canada.
John R McLaughlinDalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
M Catherine BrownProsserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, ON, Canada.
Hamad Al-SawaiheyProsserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, ON, Canada.
James RutkaDepartment of Surgery, University of Toronto, Toronto, ON, Canada.
Eric BouffetDivision of Hematology/Oncology, The Hospital for Sick Children Toronto, Toronto, ON, Canada.
Cynthia HawkinsDivision of Pathology, Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada.
A Elizabeth CairneyChildren's Hospital, London Health Sciences Centre, London, ON, Canada.
Adrianna RangerChildren's Hospital, London Health Sciences Centre, London, ON, Canada.
Adam J FlemingMcMaster Children's Hospital, Hamilton Health Sciences, Hamilton, ON, Canada.ORCID http://orcid.org/0000-0002-7194-3220
Donna JohnstonChildren's Hospital of Eastern Ontario, Ottawa, ON, Canada.
Mark GreenbergDivision of Hematology/Oncology, The Hospital for Sick Children Toronto, Toronto, ON, Canada.
David MalkinDivision of Hematology/Oncology, The Hospital for Sick Children Toronto, Toronto, ON, Canada.
Rayjean J HungProsserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, ON, Canada. rayjean.hung@lunenfeld.ca.ORCID http://orcid.org/0000-0002-4486-7496
University of Toronto · CAHospital for Sick Children · CALondon Health Sciences Centre · CALunenfeld-Tanenbaum Research Institute · CAChildren's Hospital of Eastern Ontario · CAMcMaster Children's Hospital · CAPediatric Oncology Group · CAUniversity Health Network · CA

Funding

CIHR
6 · The paper itself

Abstract

backgroundStudies to date have yielded inconclusive results as to whether maternal medical history during pregnancy, and a child's early-life medical history contribute to the development of childhood brain tumours (CBTs). This study examined associations between maternal and childhood medical history and the risk of CBTs.

methodsThe Childhood Brain Tumour Epidemiology Study of Ontario (CBREO) examined children 0-15 years of age with newly diagnosed CBTs from 1997 to 2003. Multivariable logistic regression analysis determined associations for prenatal medications and childhood medical history, adjusted for child's demographics, and maternal education. Analyses were stratified by histology. A latency period analysis was conducted using 12- and 24-month lead times.

resultsMaternal intake of immunosuppressants during the prenatal period was significantly associated with glial tumours (OR 2.73, 95% CI 1.17-6.39). Childhood intake of anti-epileptics was significantly associated with CBTs overall, after accounting for 12-month (OR 8.51, 95% CI 3.35-21.63) and 24-month (OR 6.04, 95% CI 2.06-17.70) lead time before diagnosis. No associations for other medications were found.

conclusionsThis study underscores the need to examine potential carcinogenic effects of the medication classes highlighted and of the indication of medication use. Despite possible reverse causality, increased CBT surveillance for children with epilepsy might be warranted.

Indexed as

Brain NeoplasmsPrenatal Exposure Delayed EffectsCase-Control StudiesChildFamilyFemaleHumansOntarioPregnancyRisk Factors

Identifiers

PMID37165200
PMCPMC10338441
OpenAlexW4376106635

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.