ArticleNature2023
Mitotic clustering of pulverized chromosomes from micronuclei.
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Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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50citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed.
- Micronuclear ecDNA constrains tumor cell fitness and is associated with favorable patient survival.Nature genetics · 2026Article
- Dynamic chromatin tethering of MDC1 regulates genome stability.Nucleic acids research · 2026Article
- Seeing Is Believing: Intercellular Transfer of DNA between Human Cells.Cancer research · 2026Article
- Development of a structurally distinct TopBP1 inhibitor that enhances PARP blockade and reverses osimertinib resistance.Science advances · 2026Article
- Article
- Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- A mutational scar-based genome-wide map of DNA double-strand break repair.Nature communications · 2026Article
- Loss of JAK1 Function Causes G2-M Cell-Cycle Defects Vulnerable to KIF18A Inhibition.Cancer research · 2026Article
- Micronuclei: origins, assays, mechanisms, diseases and treatments.Signal transduction and targeted therapy · 2026Review
- Genomic Reshuffling After Cell Fusion: Catalyst for Cancer Evolution and Progression.Advances in experimental medicine and biology · 2026Review
- Low-Grade Fibro-Osseous Lesions With Isolated Chromosome 12 Chromothripsis: A Distinct Entity Or a Low-Grade Central Osteosarcoma With a Novel Driver?Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2026Article
- STING signaling pathway: An oasis in the glioblastoma immune desert.Theranostics · 2026Review
- Mitotic errors as triggers of cell death and inflammation.Nature cell biology · 2026Review
- Innate immune sensing via the cGAS-STING pathway restricts extrachromosomal DNA-driven tumorigenesis.bioRxiv : the preprint server for biology · 2026Article
- CIP2A mediates mitotic recruitment of SLX4/MUS81/XPF to resolve replication stress-induced DNA lesions.Nature communications · 2025Article
- Article
- The CIP2A-TOPBP1 axis facilitates mitotic DNA repair via MiDAS and MMEJ.Nature communications · 2025Article
- Megabase-scale loss of heterozygosity provoked by CRISPR-Cas9 DNA double-strand breaks.Molecular cell · 2025Article
- The Emerging Role of the Cancerous Inhibitor of Protein Phosphatase 2A in Pulmonary Diseases.Medicina (Kaunas, Lithuania) · 2025Review
- Chromosomal tethering and mitotic transcription promote ecDNA nuclear inheritance.Molecular cell · 2025Article
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Authors and funding
14 authors.
Yu-Fen LinDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Qing Hu *Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Alice Mazzagatti *Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0003-1627-0446
Jose Espejo Valle-Inclán *European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, UK.ORCID 0000-0002-4857-5984
Elizabeth G MauraisDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Rashmi DahiyaDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Alison GuyerDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Jacob T SandersDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Justin L EngelDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-2016-3494
Giaochau NguyenDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Daniel BronderHuman Oncology and Pathogenesis Program, Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0003-1666-2896
Samuel F BakhoumHuman Oncology and Pathogenesis Program, Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Isidro Cortés-CirianoEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, UK. icortes@ebi.ac.uk.ORCID 0000-0002-2036-494X
Peter LyDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA. peter.ly@utsouthwestern.edu.ORCID 0000-0001-8946-7069
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MUTSW-UNC Center for Cell Signaling AnalysisRM1GM145399 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Kevin Michael Dean, Klaus M. Hahn · 2022 to 2026
$6.2MCancer Biology Training GrantT32CA124334 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI SHAY, JERRY WILLIAM · 2007 to 2021
$5.3MGenomic Instability from Fragmented Chromosomes in MicronucleiR35GM146610 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Peter Ly · 2022 to 2026
$2.3MCell Division Errors as a Mechanism Driving Massive Genomic RearrangementsR00CA218871 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI LY, PETER · 2019 to 2021
$676kNCI NIH HHS P30 CA008748NCI NIH HHS R00 CA218871NCI NIH HHS T32 CA124334NIGMS NIH HHS R35 GM146610NIGMS NIH HHS RM1 GM145399
Abstract
Complex genome rearrangements can be generated by the catastrophic pulverization of missegregated chromosomes trapped within micronuclei through a process known as chromothripsis
Indexed as
Chromosomes, HumanChromothripsisMicronuclei, Chromosome-DefectiveMitosisAutoantigensCarrier ProteinsCentromereDNADNA-Binding ProteinsDNA Copy Number VariationsHumansInterphaseIntracellular Signaling Peptides and ProteinsMembrane ProteinsNeoplasmsNuclear ProteinsAutoantigensCarrier ProteinsCIP2A protein, humanDNADNA-Binding ProteinsIntracellular Signaling Peptides and ProteinsMembrane ProteinsNuclear ProteinsTOPBP1 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.