Evidence map›Paper›PMID 37165189›Full record

ArticleNature2023

De novo evolution of macroscopic multicellularity.

G Ozan Bozdag, Seyed Alireza Zamani-Dahaj, Thomas C Day, Penelope C Kahn, Anthony J Burnetti, Dung T Lac, Kai Tong, Peter L Conlin, Aishwarya H Balwani, Eva L Dyer and 2 more

Abstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Evolutionary cell biology comes of age.Journal of cell science · 2025
    Article
  12. Behavioural ecology in the twenty-first century.Nature ecology & evolution · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Entanglement transition in random rod packings.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

G Ozan Bozdag *School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA. ozan.bozdag@gmail.com.ORCID 0000-0002-0931-2399
Seyed Alireza Zamani-Dahaj *Interdisciplinary Graduate Program in Quantitative Biosciences, Georgia Institute of Technology, Atlanta, GA, USA.
Thomas C DaySchool of Physics, Georgia Institute of Technology, Atlanta, GA, USA.
Penelope C KahnSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Anthony J BurnettiSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.ORCID 0000-0003-3856-8251
Dung T LacSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.ORCID 0009-0009-8480-7701
Kai TongSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Peter L ConlinSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.ORCID 0000-0002-2793-7624
Aishwarya H BalwaniSchool of Electrical & Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA.ORCID 0000-0002-9234-1632
Eva L DyerSchool of Electrical & Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
Peter J YunkerInterdisciplinary Graduate Program in Quantitative Biosciences, Georgia Institute of Technology, Atlanta, GA, USA. peter.yunker@gatech.edu.ORCID 0000-0001-8471-4171
William C RatcliffSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA. ratcliff@gatech.edu.ORCID 0000-0002-6837-8355

Funding

Using directed evolution to study the origins of multicellular development.R35GM138030 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI William Croft Ratcliff · 2020 to 2026
$2.8M
The Biophysical Foundations of Bacterial Biofilm Growth and SurvivalR35GM138354 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI Peter Yunker · 2020 to 2026
$2.0M
NIGMS NIH HHS R35 GM138030NIGMS NIH HHS R35 GM138354
6 · The paper itself

Abstract

While early multicellular lineages necessarily started out as relatively simple groups of cells, little is known about how they became Darwinian entities capable of sustained multicellular evolution

Indexed as

AcclimatizationBiological EvolutionCell AggregationSaccharomyces cerevisiaeAerobiosisAnaerobiosisCell ShapeModels, BiologicalOxygenOxygen

Identifiers

PMID37165189
PMCPMC10425966

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.