Evidence map›Paper›PMID 37165177›Full record

ArticleNeuroscience bulletin2023

The Antinociceptive Effect of Sympathetic Block is Mediated by Transforming Growth Factor β in a Mouse Model of Radiculopathy.

Debora Denardin Lückemeyer, Wenrui Xie, Arthur Silveira Prudente, Katherine A Qualls, Raquel Tonello, Judith A Strong, Temugin Berta, Jun-Ming Zhang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience bulletin, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Pain Hypersensitivity in a Mouse Model of Marfan Syndrome.Antioxidants (Basel, Switzerland) · 2026
    Article
  3. Association of theInternational journal of molecular sciences · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Debora Denardin LückemeyerPain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA.ORCID http://orcid.org/0000-0002-2231-6511
Wenrui XiePain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA.ORCID http://orcid.org/0000-0002-6692-771X
Arthur Silveira PrudentePain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA.ORCID http://orcid.org/0000-0002-8602-7911
Katherine A QuallsPain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA.ORCID http://orcid.org/0000-0003-0619-0813
Raquel TonelloDepartment of Molecular Pathobiology, Department of Neuroscience and Physiology, Neuroscience Institute, New York University, New York, NY, 10010, USA.ORCID http://orcid.org/0000-0002-2175-9804
Judith A StrongPain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA.ORCID http://orcid.org/0000-0001-9363-0551
Temugin BertaPain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA.ORCID http://orcid.org/0000-0002-4486-8288
Jun-Ming ZhangPain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA. Jun-Ming.Zhang@uc.edu.ORCID http://orcid.org/0000-0003-4300-2121
University of Cincinnati Medical Center · USNew York University · US

Funding

STUDY OF ACTIVITY-DEPENDENT SYMPATHETIC SPROUTINGR01NS045594 · NINDS · UNIVERSITY OF CINCINNATI · PI ZHANG, JUN-MING · 2004 to 2025
$8.6M
Sympathetic-mediated sensory neuron cluster firing as a novel therapeutic target for neuropathic painRF1NS113883 · NINDS · JOHNS HOPKINS UNIVERSITY · PI DONG, XINZHONG, ZHANG, JUN-MING · 2019 to 2019
$3.1M
Targeting sensory ganglia and glial signaling for the treatment of acute and chronic painR01NS113243 · NINDS · UNIVERSITY OF CINCINNATI · PI BERTA, TEMUGIN · 2019 to 2019
$2.0M
NINDS NIH HHS R01 NS045594NINDS NIH HHS R01 NS113243NINDS NIH HHS RF1 NS113883
6 · The paper itself

Abstract

Although sympathetic blockade is clinically used to treat pain, the underlying mechanisms remain unclear. We developed a localized microsympathectomy (mSYMPX), by cutting the grey rami entering the spinal nerves near the rodent lumbar dorsal root ganglia (DRG). In a chemotherapy-induced peripheral neuropathy model, mSYMPX attenuated pain behaviors via DRG macrophages and the anti-inflammatory actions of transforming growth factor-β (TGF-β) and its receptor TGF-βR1. Here, we examined the role of TGF-β in sympathetic-mediated radiculopathy produced by local inflammation of the DRG (LID). Mice showed mechanical hypersensitivity and transcriptional and protein upregulation of TGF-β1 and TGF-βR1 three days after LID. Microsympathectomy prevented mechanical hypersensitivity and further upregulated Tgfb1 and Tgfbr1. Intrathecal delivery of TGF-β1 rapidly relieved the LID-induced mechanical hypersensitivity, and TGF-βR1 antagonists rapidly unmasked the mechanical hypersensitivity after LID+mSYMPX. In situ hybridization showed that Tgfb1 was largely expressed in DRG macrophages, and Tgfbr1 in neurons. We suggest that TGF-β signaling is a general underlying mechanism of local sympathetic blockade.

Indexed as

RadiculopathyTransforming Growth Factor betaAnalgesicsAnimalsGanglia, SpinalHyperalgesiaMicePainReceptor, Transforming Growth Factor-beta Type ITransforming Growth Factor beta1AnalgesicsReceptor, Transforming Growth Factor-beta Type ITransforming Growth Factor betaTransforming Growth Factor beta1CytokineInflammationRadiculopathySympatheticTGF-β

Identifiers

PMID37165177
PMCPMC10465463
OpenAlexW4376133705

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.