ReviewNature reviews. Cardiology2023
The contribution of the exposome to the burden of cardiovascular disease.
Review in Nature reviews. Cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07207603 (Observational Cohort Pilot Study on Cardiovascular Prevention in Citizens Living in Milano-Bicocca District), which is not on this map. Cited by 102 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Observational Cohort Pilot Study on Cardiovascular Prevention in Citizens Living in Milano-Bicocca District
Who cites it
102 citing papers in PubMed, 1 synthesis or guideline pooled it, 151 citations in OpenAlex.
- National Heart Center/Saudi Heart Association 2025 Guidelines for Cardiovascular Diseases Prevention and Risk Assessment.Saudi medical journal · 2026Guideline
- Air pollution and adverse birth outcomes: a narrative review of epidemiological and mechanistic findings.Journal of environmental health science & engineering · 2026Review
- Non optimal temperatures and chronic cardiovascular diseases.Seminars in immunopathology · 2026Review
- Modeling the Exposome in Murine Cardiovascular Disease.JACC. Basic to translational science · 2026Review
- Nucleic acid aptamers: new methods for selection, target validation, molecular diagnostics and therapeutics.Signal transduction and targeted therapy · 2026Review
- Environmental Toxic Metals and Metalloids Exposure and Cardiovascular Health: Current Evidence from Oxidative Stress and Inflammatory Biomarkers as Indicators of Subclinical Cardiovascular Effects.Antioxidants (Basel, Switzerland) · 2026Review
- A Comparative Analysis of Aging Across Causes of Death.Evolutionary applications · 2026Article
- Environmental Mixture-Health Associations: Current Analytical Practice and Reporting Recommendations.China CDC weekly · 2026Article
- A Perfect Storm of Pollutants: Environmental Mixtures in the Pathogenesis of Atherosclerosis.International journal of molecular sciences · 2026Review
- Review
- The impact of PMScientific reports · 2026Article
- From Exposure to Outcome: Air Pollution-Induced Oxidative Stress as a Determinant of Early and Late Outcomes After Coronary Artery Bypass Grafting.Antioxidants (Basel, Switzerland) · 2026Review
- The environmental exposome in heart failure risk and progression.Nature reviews. Cardiology · 2026Review
- Association of the C-reactive protein-triglyceride glucose index with new-onset myocardial infarction risk: a prospective cohort study.Scientific reports · 2026Article
- Review
- Clustering effects on the reactivity of alkoxy radicals: rate coefficients ofPhysical chemistry chemical physics : PCCP · 2026Article
- Machine-learning-based cardiovascular mortality prediction using a cumulative PMScientific reports · 2026Observational
- A transistor-based point-of-care assay with lipid-capped sensory interface for clinical profiling of cardiovascular diseases.National science review · 2026Article
- Environmental Stressors and Cardiovascular Health: Acting Locally for Global Impact in a Changing World: A Statement of the European Society of Cardiology, the American College of Cardiology, the American Heart Association, and the World Heart Federation.Journal of the American College of Cardiology · 2026Article
- Exploring the exposome and unexplained variance in biological ageing - insights from a longitudinal twin study in adolescence and early adulthood.medRxiv : the preprint server for health sciences · 2026Article
42 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Large epidemiological and health impact assessment studies at the global scale, such as the Global Burden of Disease project, indicate that chronic non-communicable diseases, such as atherosclerosis and diabetes mellitus, caused almost two-thirds of the annual global deaths in 2020. By 2030, 77% of all deaths are expected to be caused by non-communicable diseases. Although this increase is mainly due to the ageing of the general population in Western societies, other reasons include the increasing effects of soil, water, air and noise pollution on health, together with the effects of other environmental risk factors such as climate change, unhealthy city designs (including lack of green spaces), unhealthy lifestyle habits and psychosocial stress. The exposome concept was established in 2005 as a new strategy to study the effect of the environment on health. The exposome describes the harmful biochemical and metabolic changes that occur in our body owing to the totality of different environmental exposures throughout the life course, which ultimately lead to adverse health effects and premature deaths. In this Review, we describe the exposome concept with a focus on environmental physical and chemical exposures and their effects on the burden of cardiovascular disease. We discuss selected exposome studies and highlight the relevance of the exposome concept for future health research as well as preventive medicine. We also discuss the challenges and limitations of exposome studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.