Evidence map›Paper›PMID 37165097›Full record

ArticleScientific reports2023

Exploring the role of empathy in prolonged grief reactions to bereavement.

Takuya Yoshiike, Francesco Benedetti, Yoshiya Moriguchi, Benedetta Vai, Veronica Aggio, Keiko Asano, Masaya Ito, Hiroki Ikeda, Hidefumi Ohmura, Motoyasu Honma and 4 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Observational
  2. Prolonged grief disorder in later life: advancing our understanding of biopsychosocial mechanisms to guide future personalized interventions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 2 countries.

Takuya YoshiikeDepartment of Sleep-Wake Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8553, Japan. yoshiike@ncnp.go.jp.
Francesco BenedettiPsychiatry and Clinical Psychobiology, Division of Neuroscience, Scientific Institute Ospedale San Raffaele, Milan, Italy.
Yoshiya MoriguchiDepartment of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Japan.
Benedetta VaiPsychiatry and Clinical Psychobiology, Division of Neuroscience, Scientific Institute Ospedale San Raffaele, Milan, Italy.
Veronica AggioPsychiatry and Clinical Psychobiology, Division of Neuroscience, Scientific Institute Ospedale San Raffaele, Milan, Italy.
Keiko AsanoDepartment of Human Sciences, Faculty of Human Sciences, Musashino University, Tokyo, Japan.
Masaya ItoNational Center for Cognitive Behavior Therapy and Research, National Center of Neurology and Psychiatry, Kodaira, Japan.
Hiroki IkedaNational Institute of Occupational Safety and Health, Japan Organization of Occupational Health and Safety, Kawasaki, Japan.
Hidefumi OhmuraDepartment of Information Sciences, Faculty of Science and Technology, Tokyo University of Science, Noda, Japan.
Motoyasu HonmaDepartment of Physiology, Showa University School of Medicine, Tokyo, Japan.
Naoto YamadaDepartment of Psychiatry, Shiga University of Medical Science, Otsu, Japan.
Yoshiharu KimDepartment of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Japan.
Satomi NakajimaDepartment of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Japan.
Kenichi KuriyamaDepartment of Sleep-Wake Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8553, Japan.
National Center of Neurology and Psychiatry · JPNational Institute of Mental Health · JPVita-Salute San Raffaele University · ITIRCCS Ospedale San Raffaele · ITMusashino University · JPNational Institute of Occupational Safety and Health · JPShiga University of Medical Science · JPShowa University · JPTokyo University of Science · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Grief reactions to the bereavement of a close individual could involve empathy for pain, which is fundamental to social interaction. To explore whether grief symptoms interact with social relatedness to a person to whom one directs empathy to modulate the expression of empathy, we administered an empathy task to 28 bereaved adults during functional magnetic resonance imaging, in which participants were subliminally primed with facial stimuli (e.g., faces of their deceased or living relative, or a stranger), each immediately followed by a visual pain stimulus. Individuals' grief severity promoted empathy for the pain stimulus primed with the deceased's face, while it diminished the neural response to the pain stimulus primed with the face of either their living relative or a stranger in the medial frontal cortex (e.g., the right dorsal anterior cingulate cortex). Moreover, preliminary analyses showed that while the behavioral empathic response was promoted by the component of "longing" in the deceased priming condition, the neural empathic response was diminished by the component of "avoidance" in the stranger priming condition. Our results suggest an association between grief reactions to bereavement and empathy, in which grief symptoms interact with interpersonal factors to promote or diminish empathic responses to others' pain.

Indexed as

EmpathyGriefAdultFrontal LobeGyrus CinguliHumansMagnetic Resonance ImagingPain

Identifiers

PMID37165097
PMCPMC10172345
OpenAlexW4376133516

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.