ReviewNature reviews. Neuroscience2023
Post-injury pain and behaviour: a control theory perspective.
Review in Nature reviews. Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Neurofeedback modulation of insula activity via MEG-based brain-machine interface: a double-blind randomized controlled crossover trial.Communications biology · 2025Trial
- A Holistic and Dynamic Network-Level View of the Autonomic Nervous System.Annual review of biomedical engineering · 2026Review
- Brain signatures of nociplastic pain: Fibromyalgia Index and descending modulation at population level.Brain : a journal of neurology · 2026Article
- Why sleep matters in chronic pain: evidence across the lifespan.EBioMedicine · 2026Review
- Homeostasis after injury: How intertwined inference and control underpin post-injury pain and behaviour.PLoS computational biology · 2026Article
- Immersive virtual reality for pediatric burn pain and early rehabilitation.Frontiers in pediatrics · 2026Article
- Neural Associative Skill Memories for Safer Robotics and Modeling Human Sensorimotor Repertoires.Neural computation · 2025Article
- Bayesian attenuation of offset analgesia filters out random disturbances in noxious stimuli.Pain reports · 2025Article
- Direction Matters: A Crossover Study on Motor Adaptations to Movement-Evoked Pain Induced in the Lumbar Region.European journal of pain (London, England) · 2025Article
- Review
- Article
- Article
- Harnessing Extended Reality for Neurocognitive Training in Chronic Pain: State of the Art, Opportunities, and Future Directions.Healthcare (Basel, Switzerland) · 2025Review
- Enhanced behavioural and neural sensitivity to punishments in chronic pain and fatigue.Brain : a journal of neurology · 2025Article
- Neuroimmune Pain and Its Manipulation by Pathogens.Evolutionary applications · 2025Article
- A History of Pain Studies and Changing Attitudes to the Welfare of Crustaceans.Animals : an open access journal from MDPI · 2025Review
- Injury alters sensory, motor, and integrative elements underlying operant conditioning in the medicinal leech.PloS one · 2025Article
- Placebo treatment affects brain systems related to affective and cognitive processes, but not nociceptive pain.Nature communications · 2024Article
- A New Look at Gray Matter Decreases in Chronic Pain.Biological psychiatry · 2024Article
- Behavioural Indicators of Pain and Suffering in Arthropods and Might Pain Bite Back?Animals : an open access journal from MDPI · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Injuries of various types occur commonly in the lives of humans and other animals and lead to a pattern of persistent pain and recuperative behaviour that allows safe and effective recovery. In this Perspective, we propose a control-theoretic framework to explain the adaptive processes in the brain that drive physiological post-injury behaviour. We set out an evolutionary and ethological view on how animals respond to injury, illustrating how the behavioural state associated with persistent pain and recuperation may be just as important as phasic pain in ensuring survival. Adopting a normative approach, we suggest that the brain implements a continuous optimal inference of the current state of injury from diverse sensory and physiological signals. This drives the various effector control mechanisms of behavioural homeostasis, which span the modulation of ongoing motivation and perception to drive rest and hyper-protective behaviours. However, an inherent problem with this is that these protective behaviours may partially obscure information about whether injury has resolved. Such information restriction may seed a tendency to aberrantly or persistently infer injury, and may thus promote the transition to pathological chronic pain states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.