ArticleEye (London, England)2023
Comparison of diabetic retinopathy severity grading on ETDRS 7-field versus ultrawide-field assessment.
Article in Eye (London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Effect of a Multifactorial Intervention on Retinopathy in People With Type 2 Diabetes: A Secondary Analysis of the J-DOIT3 Randomized Clinical Trial.JAMA ophthalmology · 2025Trial
- Bidirectional association between obstructive sleep apnea and diabetic retinopathy: a severity-stratified systematic review and meta-analysis with GRADE assessment.Acta diabetologica · 2026Review
- Predicting progression to proliferative diabetic retinopathy using automated versus manual quantification of retinal haemorrhages.Eye (London, England) · 2026Article
- Quantifying changes in retinal non-perfusion over time with ultra-widefield fluorescein angiography following intravitreal treatment of diabetic retinopathy.BMC ophthalmology · 2026Article
- Automated Nonperfusion Quantification in Diabetic Retinopathy on Ultra-Widefield Swept-Source OCT Angiography.Ophthalmology science · 2026Article
- Ultra-Widefield Fluorescein Angiographic Quantitative Leakage Parameters and Clinical Outcomes in Nonproliferative Diabetic Retinopathy.JAMA ophthalmology · 2026Observational
- A Hierarchical Deep Learning Architecture for Diagnosing Retinal Diseases Using Cross-Modal OCT to Fundus Translation in the Lack of Paired Data.Journal of imaging · 2026Article
- Ultra-widefield color fundus photography in diabetic retinopathy: from panretinal assessment to multimodal integration.Frontiers in medicine · 2026Review
- Artificial intelligence-based analysis of retinal vascular changes in the preclinical and early stages of diabetic retinopathy using ultra-widefield fundus imaging: an observational cross-sectional study.Frontiers in medicine · 2026Article
- Progression of diabetic retinopathy in a longitudinal real-world study of patients in primary care.BMC ophthalmology · 2025Observational
- 3D-OCTA Evaluation of Retinal Microcirculation Abnormalities in the Macular Region of Eyes With Anisometropic Amblyopia.Translational vision science & technology · 2025Article
- Microvascular Metrics on Diabetic Retinopathy Severity: Analysis of Diabetic Eye Images from Real-World Data.Biomedicines · 2024Article
- The clinical evaluation of a widefield lens to expand the field of view in optical coherence tomography (OCT-A).Scientific reports · 2024Article
- Comparison of Standard 7-Field, Clarus, and Optos Ultrawidefield Imaging Systems for Diabetic Retinopathy (COCO Study).Ophthalmology scienceArticle
- Peripheral retinal lesions in diabetic retinopathy on ultra-widefield imaging.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological SocietyArticle
- Predicting intravitreal treatment response using ultrawide-field angiographic biomarkers in diabetic retinopathy.Advances in ophthalmology practice and researchArticle
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
objectivesTo compare the diabetic retinopathy (DR) severity level determined when considering only the ETDRS 7-field region versus the entire ultrawidefield (UWF) image.
methodsIn this retrospective, cross-sectional study, UWF pseudocolor images were graded on the Eyenuk image viewing, grading, and annotation platform for the severity of DR considering only the regions within the ETDRS 7-fields as well as the entire UWF image using two different protocols: 1) the simple International Classification of Diabetic Retinopathy (ICDR) scale and 2) the more complex DRCR.net Protocol AA grading scale.
resultsA total of 250 eyes from 157 patients were included in this analysis. Six eyes (2.4%) demonstrated a discrepancy in severity level between the ETDRS 7-field region and the entire UWF image when using the ICDR classification system. The discrepancies were due to the presence of lesions [intraretinal haemorrhage (n = 2), neovascular disease (n = 4)] in the peripheral fields which were not identified in the ETDRS 7-fields. Fourteen eyes (5.6%) had a discrepancy in severity level between the ETDRS 7-field region and the entire UWF image when using the ETDRS DRSS Protocol AA grading scale. The discrepancies were due to the presence of a higher level of disease [intraretinal haemorrhage (n = 4), neovascularization (n = 4), preretinal haemorrhage (n = 2), scatter laser scars (n = 4)] in the peripheral fields.
conclusionAlthough considering regions outside of the ETDRS 7-fields altered the DR severity level assessment in <5% of cases in this cohort, significant and potentially vision-threatening lesions including neovascularization and preretinal haemorrhage were identified in these peripheral regions. This highlights the importance of evaluating the entire UWF region when assessing patients with diabetic retinopathy.
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