Evidence map›Paper›PMID 37164920›Full record

ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2023

Mechanism for effect of tanshinone IIA on alleviating cardiomyocyte injury induced by oxygen glucose deprivation.

Qin Xu, Zhaohua Wang, Sanli You, Lili Yuan, He Li

Open access · greenAbstract read
In one paragraph

Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Qin XuDepartment of Cardiology, Brain Hospital of Hunan Province, Changsha 410007, China. 272835047@qq.com.
Zhaohua WangDepartment of Cardiology, Brain Hospital of Hunan Province, Changsha 410007, China.
Sanli YouDepartment of Cardiology, Brain Hospital of Hunan Province, Changsha 410007, China.
Lili YuanDepartment of Cardiology, Brain Hospital of Hunan Province, Changsha 410007, China.
He LiDepartment of Cardiology, Brain Hospital of Hunan Province, Changsha 410007, China. 8970269@qq.com.
Second People Hospital of Hunan · CN

Funding

the Scientific Research Program from the Health Comission of Hunan Province 202103010510 and C20190620the Traditional Chinese Medicine Scientific Research Program of Hunan Province 201943 and D2022024
6 · The paper itself

Abstract

objectivesTanshinone IIA has a wide range of myocardial protective effects.

methodsOGD model was established in rat H9C2 cardiomyocytes. siRNA was transfected to reduce

resultsCompared with the control group, the leakage rate of LDH, the content of IL-1β and IL-18 in culture medium, and the protein expression level of p-NF-κB were increased in the OGD group (

conclusionsTanshinone IIA inhibits NF-κB activity and attenuates OGD-induced inflammatory injury of cardiomyocytes through up-regulating AK003290.

Indexed as

Myocytes, CardiacNF-kappa BAbietanesAnimalsGlucoseInterleukin-18OxygenRatsRNA, Small InterferingSignal TransductionAbietanesGlucoseInterleukin-18NF-kappa BOxygenRNA, Small InterferingtanshinoneAK003290cardiomyocyte injuryinflammatorylong noncoding RNAnuclear factor- κBoxygen glucose deprivationtanshinone IIA

Identifiers

PMID37164920
PMCPMC10930080
OpenAlexW4376133177

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.