Evidence map›Paper›PMID 37164453›Full record

SynthesisBMJ open2023

Routine antibiotics for infants less than 6 months of age with growth failure/faltering: a systematic review.

Aamer Imdad, Fanny F Chen, Melissa François, Momal Sana, Emily Tanner-Smith, Abigail Smith, Olivia Tsistinas, Jai K Das, Zulfiqar Ahmed Bhutta

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 4 countries.

Aamer ImdadDivision of Gastroenterology, Department of Pediatrics, SUNY Upstate Medical University, Syracuse, New York, USA imdada@upstate.edu.ORCID 0000-0002-7026-0006
Fanny F ChenNorton College of Medicine, SUNY Upstate Medical University, Syracuse, New York, USA.
Melissa FrançoisNorton College of Medicine, SUNY Upstate Medical University, Syracuse, New York, USA.
Momal SanaMonash Health, Clayton, Victoria, Australia.
Emily Tanner-SmithCollege of Education, University of Oregon, Eugene, Oregon, USA.ORCID 0000-0002-5313-0664
Abigail SmithHealth Science Library, SUNY Upstate Medical University, Syracuse, New York, USA.
Olivia TsistinasHealth Science Library, SUNY Upstate Medical University, Syracuse, New York, USA.
Jai K DasDivision of Women and Child Health, Aga Khan University, Karachi, Pakistan.ORCID 0000-0002-2966-7162
Zulfiqar Ahmed BhuttaDivision of Women and Child Health, Aga Khan University, Karachi, Pakistan.
SUNY Upstate Medical University · USAga Khan University · PKMonash Health · AUUniversity of Oregon · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis systematic review commissioned by WHO aimed to synthesise evidence from current literature on the effects of systematically given, routine use of antibiotics for infants under 6 months of age with growth failure/faltering. SETTINGS: Low-income and middle-income countries.

participantsThe study population was infants less than 6 months of age with growth failure/faltering.

interventionThe intervention group was infants who received no antibiotics or antibiotics other than those recommended in 2013 guidelines by WHO to treat childhood severe acute malnutrition. The comparison group was infants who received antibiotics according to the aforementioned guidelines. PRIMARY AND SECONDARY OUTCOMES: The primary outcome was all-cause mortality, and secondary outcomes: clinical deterioration, antimicrobial resistance, recovery from comorbidity, adverse events, markers of intestinal inflammation, markers of systemic inflammation, hospital-acquired infections and non-response. The Grading of Recommendations Assessment, Development and Evaluation approach was considered to report the overall evidence quality for an outcome.

resultsWe screened 5137 titles and abstracts and reviewed the full text of 157 studies. None of the studies from the literature search qualified to answer the question for this systematic review.

conclusionsThere is a paucity of evidence on the routine use of antibiotics for the treatment of malnutrition in infants less than 6 months of age. Future studies with adequate sample sizes are needed to assess the potential risks and benefits of antibiotics in malnourished infants under 6 months of age. PROSPERO REGISTRATION NUMBER: CRD42021277073.

Indexed as

Infant Nutrition DisordersMalnutritionSevere Acute MalnutritionAnti-Bacterial AgentsChildHumansInfantInflammationAnti-Bacterial Agentsinfectious diseasesnutritionpublic health

Identifiers

PMID37164453
PMCPMC10174012
OpenAlexW4376131820

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.