Evidence map›Paper›PMID 37164391›Full record

ArticleKlinische Monatsblatter fur Augenheilkunde2023

Severe Complications after Corneal Collagen Cross-Linking (CXL).

Frank Blaser, Sandrine Zweifel, Maximilian Robert Justus Wiest, Anahita Bajka, Sadiq Said, Daniel Barthelmes, Daniel Rudolf Muth

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Klinische Monatsblatter fur Augenheilkunde, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Frank BlaserOphthalmology and Eye Clinic, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Sandrine ZweifelOphthalmology and Eye Clinic, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Maximilian Robert Justus WiestOphthalmology and Eye Clinic, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Anahita BajkaOphthalmology and Eye Clinic, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Sadiq SaidOphthalmology and Eye Clinic, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Daniel BarthelmesOphthalmology and Eye Clinic, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Daniel Rudolf MuthOphthalmology and Eye Clinic, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
University Hospital of Zurich · CHUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo present a case series of rare and severe complications after corneal collagen cross-linking (CXL) of keratoconus patients.

methodsSingle-center descriptive case series covering the period of 2012 to 2022 at the Department of Ophthalmology at the University Hospital, Zurich, Switzerland.

resultsWe present four eyes of four patients that showed severe unusual complications within the first month after CXL. Three patients had been treated with the classical epithelium-off "Dresden" protocol. One patient had been treated with the accelerated epithelium-off protocol. One patient presented with extensive corneal edema due to rubbing the eye after treatment. Two patients showed a bacterial infectious keratitis: one due to

conclusionSevere complications after CXL remain rare. Most common causes are complications that are not directly associated with the treatment as such. Those indirect complications occur after the treatment during the healing course of the epithelium. Associations with bandage contact lenses, topical steroids, atopic disease, and inappropriate patient behavior are often suspected. Correctly performed corneal scrapings with repeated microbiological analysis and a detailed patient history are essential for establishing the correct diagnosis, especially in complicated cases that do not respond to a standard therapeutic regimen. This case series supports the efforts that are currently taken to improve the CXL technique in a way that postoperative complications are further reduced. A more efficient epithelium-on technique might be a step in that direction.

Indexed as

Corneal Cross-LinkingKeratoconusAdolescentAdultChildCorneal EdemaHumansKeratitisMaleTreatment Outcome

Identifiers

PMID37164391
PMCPMC10129411
OpenAlexW4366997783

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.