Evidence map›Paper›PMID 37164238›Full record

ArticleMucosal immunology2023

A2Ar-dependent PD-1+ and TIGIT+ Treg cells have distinct homing requirements to suppress autoimmune uveitis in mice.

Kayleigh Peters, Trisha McDonald, Fauziyya Muhammad, Marisa Walsh, Kayla Drenen, Alyssa Montieth, C Stephen Foster, Darren J Lee

Open access · hybridAbstract read
In one paragraph

Article in Mucosal immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Adenosine-mediated immune responses in inflammatory bowel disease.Frontiers in cell and developmental biology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Kayleigh PetersDepartment of Ophthalmology/Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, USA.
Trisha McDonaldDepartment of Ophthalmology/Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, USA.
Fauziyya MuhammadDepartment of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, USA.
Marisa WalshMassachusetts Eye Research and Surgery Institute, Waltham, USA; Ocular Immunology and Uveitis Foundation, Waltham, USA.
Kayla DrenenMassachusetts Eye Research and Surgery Institute, Waltham, USA; Ocular Immunology and Uveitis Foundation, Waltham, USA.
Alyssa MontiethMassachusetts Eye Research and Surgery Institute, Waltham, USA; Ocular Immunology and Uveitis Foundation, Waltham, USA.
C Stephen FosterMassachusetts Eye Research and Surgery Institute, Waltham, USA; Ocular Immunology and Uveitis Foundation, Waltham, USA; Harvard Medical School, Boston, USA.
Darren J LeeDepartment of Ophthalmology/Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, USA; Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, USA; Department of Ophthalmology and Visual Sciences, University of Massachusetts Chan Medical School, Worcester, USA. Electronic address: Darren.lee12@umassmed.edu.
Massachusetts Eye Research and Surgery Institute · USDean McGee Eye Institute · USUniversity of Oklahoma Health Sciences Center · USOcular Immunology and Uveitis Foundation · US

Funding

P30-CENTER CORE GRANT FOR VISION RESEARCHP30EY021725 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Michelle C Callegan, MICHAEL H ELLIOTT · 2011 to 2026
$10.5M
Immunobiology of EAU Recovery Through the Melanocortin-Adenosinergic PathwayR01EY024951 · NEI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LEE, DARREN JAMES · 2015 to 2024
$3.5M
NEI NIH HHS P30 EY021725NEI NIH HHS R01 EY024951
6 · The paper itself

Abstract

The proper function of regulatory T cells (Tregs) to suppress inflammation requires homing to the correct tissue site. Resolution of autoimmune uveitis generates distinct programmed death receptor 1 (PD-1

Indexed as

Autoimmune DiseasesT-Lymphocytes, RegulatoryUveitisAnimalsInflammationMiceReceptor, Adenosine A2AReceptors, CCR7Receptors, ImmunologicReceptor, Adenosine A2AReceptors, CCR7Receptors, Immunologic

Identifiers

PMID37164238
PMCPMC10512849
OpenAlexW4376131151

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.