Evidence map›Paper›PMID 37163770›Full record

ArticleJournal of the American Society for Mass Spectrometry2023

Establishing Quality Control Procedures for Large-Scale Plasma Proteomics Analyses.

Khiry L Patterson, Albert B Arul, Min Ji Choi, Nekesa C Oliver, Marsalas D Whitaker, Angel C Bodrick, Julia B Libby, Shania Hansen, Logan Dumitrescu, Katherine A Gifford and 3 more

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Plasma von Willebrand Factor and ADAMTS13 Interact WithJournal of the American Heart Association · 2026
    Article
  4. Article
  5. LC-MS/MS proteomics identifies plasma proteins related to cognition over 9-year follow-up.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Khiry L PattersonDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.
Albert B ArulDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.
Min Ji ChoiDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.
Nekesa C OliverDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.
Marsalas D WhitakerDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.
Angel C BodrickDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.
Julia B LibbyDepartment of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
Shania HansenVanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, Tennessee 37212, United States.
Logan DumitrescuDepartment of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
Katherine A GiffordDepartment of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
Angela L JeffersonDepartment of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
Timothy J HohmanVanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, Tennessee 37212, United States.
Renã A S RobinsonDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID 0000-0001-6307-8671
Vanderbilt University · USVanderbilt University Medical Center · USMeharry Medical College · US

Funding

Vanderbilt Memory & Aging ProjectR01AG034962 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI JEFFERSON, ANGELA L. · 2011 to 2025
$24.1M
Subjective Cognitive Decline in OIder AdultsR01AG062826 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GIFFORD, KATHERINE A., JEFFERSON, ANGELA L. · 2020 to 2024
$4.1M
Proteomics of Hypertension and Alzheimer's Disease in African AmericansR01AG064950 · NIA · VANDERBILT UNIVERSITY · PI ROBINSON, RENA A. S. · 2019 to 2023
$4.1M
Vanderbilt Interdisciplinary Training Program in Alzheimer's DiseaseT32AG058524 · NIA · VANDERBILT UNIVERSITY · PI ANGELA L. JEFFERSON · 2018 to 2026
$3.5M
White matter and small vessel disease in older adultsR01AG056534 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI JEFFERSON, ANGELA L. · 2017 to 2021
$3.2M
NIA NIH HHS R01 AG034962NIA NIH HHS R01 AG056534NIA NIH HHS R01 AG062826NIA NIH HHS R01 AG064950NIA NIH HHS T32 AG058524
6 · The paper itself

Abstract

Proteomics research has been transformed due to high-throughput liquid chromatography (LC-MS/MS) tandem mass spectrometry instruments combined with highly sophisticated automated sample preparation and multiplexing workflows. However, scaling proteomics experiments to large sample cohorts (hundreds to thousands) requires thoughtful quality control (QC) protocols. Robust QC protocols can help with reproducibility, quantitative accuracy, and provide opportunities for more decisive troubleshooting. Our laboratory conducted a plasma proteomics study of a cohort of

Indexed as

ProteomicsTandem Mass SpectrometryChromatography, LiquidHumansPeptidesQuality ControlReproducibility of ResultsPeptidesliquid chromatographymass spectrometryplasmaproteinsproteomicsquality control

Identifiers

PMID37163770
PMCPMC12204224
OpenAlexW4376109651

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.