Evidence map›Paper›PMID 37163687›Full record

ArticleAnalytical chemistry2023

Parahydrogen in Reversible Exchange Induces Long-Lived

Keilian MacCulloch, Austin Browning, Patrick TomHon, Sören Lehmkuhl, Eduard Y Chekmenev, Thomas Theis

Abstract read
In one paragraph

Article in Analytical chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Ultra-low fieldCommunications chemistry · 2026
    Article
  3. Benchtop NMR signal enhancement of metabolites in urine extract using SABRE.Chemical communications (Cambridge, England) · 2026
    Article
  4. The journal of physical chemistry. B · 2025
    Article
  5. EfficientJournal of magnetic resonance open · 2025
    Article
  6. SABRE-SHEATH hyperpolarizedChemical communications (Cambridge, England) · 2025
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Keilian MacCullochDepartment of Chemistry, North Carolina State University, Raleigh, North Carolina 27606, United States.ORCID 0000-0002-4506-5057
Austin BrowningDepartment of Chemistry, North Carolina State University, Raleigh, North Carolina 27606, United States.
Patrick TomHonDepartment of Chemistry, North Carolina State University, Raleigh, North Carolina 27606, United States.ORCID 0000-0003-3202-9812
Sören LehmkuhlDepartment of Chemistry, North Carolina State University, Raleigh, North Carolina 27606, United States.ORCID 0000-0002-1321-7677
Eduard Y ChekmenevDepartment of Chemistry, Wayne State University, Detroit, Michigan 48202, United States.ORCID 0000-0002-8745-8801
Thomas TheisDepartment of Chemistry, North Carolina State University, Raleigh, North Carolina 27606, United States.ORCID 0000-0001-6779-9978

Funding

Molecular MRI of Brain Metabolism Enabled by Long-Lived Spin StatesR01EB029829 · NIBIB · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI THEIS, THOMAS · 2020 to 2020
$807k
Molecular imaging with a hyperpolarized Vitamin ShotR21EB025313 · NIBIB · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI THEIS, THOMAS · 2018 to 2019
$661k
Magnetic Resonance Spectroscopy and Molecular Imaging of Metabolic Pathways in CancerR21CA220137 · NCI · WAYNE STATE UNIVERSITY · PI CHEKMENEV, EDUARD · 2017 to 2019
$390k
NCI NIH HHS R21 CA220137NIBIB NIH HHS R01 EB029829NIBIB NIH HHS R21 EB025313
6 · The paper itself

Abstract

Hyperpolarization modalities overcome the sensitivity limitations of NMR and unlock new applications. Signal amplification by reversible exchange (SABRE) is a particularly cheap, quick, and robust hyperpolarization modality. Here, we employ SABRE for simultaneous chemical exchange of parahydrogen and nitrile-containing anticancer drugs (letrozole or anastrozole) to enhance

Indexed as

Antineoplastic AgentsMagnetic Resonance ImagingAnastrozoleLetrozoleMagnetic Resonance SpectroscopyAnastrozoleAntineoplastic AgentsLetrozole

Identifiers

PMID37163687
PMCPMC10939174

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.