ArticleSchizophrenia bulletin2023
Disturbed Oligodendroglial Maturation Causes Cognitive Dysfunction in Schizophrenia: A New Hypothesis.
Article in Schizophrenia bulletin, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evaluating Monitoring Guidelines of Clozapine-Induced Adverse Effects: a Systematic Review.CNS drugs · 2024Pooled it
- Effects of quetiapine on cognitive functioning in schizophrenia: evidence for the remyelination hypothesis?European archives of psychiatry and clinical neuroscience · 2026Article
- The deficit of oligodendrocyte family cells in layer 3 of the dorsal anterior cingulate cortex in schizophrenia: possible interactions with dysfunction and altered microanatomy.European archives of psychiatry and clinical neuroscience · 2026Article
- Review
- Deficit of oligodendrocyte family cells in layer 5 of the dorsal anterior cingulate cortex in schizophrenia.European archives of psychiatry and clinical neuroscience · 2026Article
- Mice lacking two alleles of the schizophrenia risk geneFrontiers in cellular neuroscience · 2026Article
- Reducing functional dysconnectivity in people with schizophrenia spectrum disorders.BJPsych open · 2025Article
- Neural and somatic mechanisms driving clinical improvements in post-acute schizophrenia spectrum disorders.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- White matter microstructure changes across the lifespan: a meta-analysis of longitudinal diffusion MRI studies.bioRxiv : the preprint server for biology · 2025Article
- Deficit of satellite oligodendrocytes of neurons in the rostral part of the head of the caudate nucleus in schizophrenia.European archives of psychiatry and clinical neuroscience · 2025Article
- Aerobic exercise therapy in severe mental disorders: from methods to underlying mechanisms.European archives of psychiatry and clinical neuroscience · 2025Article
- Urolithin A alleviates schizophrenic-like behaviors and cognitive impairment in rats through modulation of neuroinflammation, neurogenesis, and synaptic plasticity.Scientific reports · 2025Article
- Multiomic single-cell profiling identifies critical regulators of postnatal brain.Nature genetics · 2025Article
- Glial cell deficits are a key feature of schizophrenia: implications for neuronal circuit maintenance and histological differentiation from classical neurodegeneration.Molecular psychiatry · 2025Review
- Physical Exercise Benefits Cognition: A Narrative Review of Evidence and Possible Mechanisms.Advances in neurobiology · 2025Review
- Genetic association between gene expression profiles in oligodendrocyte precursor cells and psychiatric disorders.Frontiers in psychiatry · 2025Article
- Neuroinflammation and schizophrenia - is there a link?Frontiers in psychiatry · 2024Article
- Cellular pathology in the limbic system in schizophrenia.European archives of psychiatry and clinical neuroscience · 2023Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
background and hypothesisCognitive impairment is a hallmark of schizophrenia, but no effective treatment is available to date. The underlying pathophysiology includes disconnectivity between hippocampal and prefrontal brain regions. Supporting evidence comes from diffusion-weighted imaging studies that suggest abnormal organization of frontotemporal white matter pathways in schizophrenia. STUDY
designHere, we hypothesize that in schizophrenia, deficient maturation of oligodendrocyte precursor cells (OPCs) into mature oligodendrocytes substantially contributes to abnormal frontotemporal macro- and micro-connectivity and subsequent cognitive deficits. STUDY
resultsOur postmortem studies indicate a reduced oligodendrocyte number in the cornu ammonis 4 (CA4) subregion of the hippocampus, and others have reported the same histopathological finding in the dorsolateral prefrontal cortex. Our series of studies on aerobic exercise training showed a volume increase in the hippocampus, specifically in the CA4 region, and improved cognition in individuals with schizophrenia. The cognitive effects were subsequently confirmed by meta-analyses. Cell-specific schizophrenia polygenic risk scores showed that exercise-induced CA4 volume increase significantly correlates with OPCs. From animal models, it is evident that early life stress and oligodendrocyte-related gene variants lead to schizophrenia-related behavior, cognitive deficits, impaired oligodendrocyte maturation, and reduced myelin thickness.
conclusionsBased on these findings, we propose that pro-myelinating drugs (e.g., the histamine blocker clemastine) combined with aerobic exercise training may foster the regeneration of myelin plasticity as a basis for restoring frontotemporal connectivity and cognition in schizophrenia.
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