Evidence map›Paper›PMID 37163616›Full record

ArticleScience translational medicine2023

Autologous neutralizing antibodies increase with early antiretroviral therapy and shape HIV rebound after treatment interruption.

Elmira Esmaeilzadeh, Behzad Etemad, Christy L Lavine, Lauren Garneau, Yijia Li, James Regan, Colline Wong, Radwa Sharaf, Elizabeth Connick, Paul Volberding and 3 more

Open access · greenAbstract read
In one paragraph

Article in Science translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Review
  3. How Vaccinating People Living With HIV May Guide bNAb‑Based Vaccines.Journal of the International AIDS Society · 2026
    Article
  4. The elite controller phenotype.Current opinion in HIV and AIDS · 2026
    Review
  5. Article
  6. Article
  7. CD8Nature · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. CD8medRxiv : the preprint server for health sciences · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Viral and immune predictors of HIV posttreatment control.Current opinion in HIV and AIDS · 2025
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Elmira EsmaeilzadehBrigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0009-0007-7481-8285
Behzad EtemadBrigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Christy L LavineBeth Israel Deaconess Medical Center, Boston, MA 02215, USA.ORCID 0000-0001-6135-0547
Lauren GarneauBeth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Yijia LiBrigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-5300-0571
James ReganBrigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-0449-2295
Colline WongBrigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Radwa SharafBrigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-5214-380X
Elizabeth ConnickUniversity of Arizona, Tucson, AZ 85724, USA.ORCID 0000-0002-0465-6248
Paul VolberdingUniversity of California, San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0002-9608-192X
Manish SagarBoston University Chobanian and Avedesian School of Medicine, Boston, MA 02118, USA.ORCID 0000-0001-9803-6594
Michael S SeamanBeth Israel Deaconess Medical Center, Boston, MA 02215, USA.ORCID 0000-0001-6444-3562
Jonathan Z LiBrigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-9914-9662
Brigham and Women's Hospital · USBeth Israel Deaconess Medical Center · USBoston University · USUniversity of Arizona · USUniversity of California, San Francisco · US

Funding

Leadership and Operations Center (LOC), AIDS Clinical Trials Group (ACTG); LOC 1/UM1AI068636 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph J Eron, RAJESH T GANDHI · 2011 to 2026
$1073.1M
Statistical and Data Management Center (SDMC), AIDS Clinical Trials Group (ACTG)UM1AI068634 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Marlene Ann Cooper, Michael David Hughes · 2011 to 2026
$246.6M
Validation, CLIA and Qualification (VQC): Enhancing the RS ratio as a tool for AIDS Clinical Trial Group (ACTG) tuberculosis trialsUM1AI106701 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Grace M Aldrovandi · 2014 to 2026
$116.8M
The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI RAJESH T GANDHI · 2004 to 2026
$94.4M
Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI CURT G BECKWITH · 1998 to 2026
$51.7M
Delaney AIDS Research Enterprise to Cure HIVUM1AI164560 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS, Sharon Ruth Lewin · 2021 to 2026
$32.0M
High-Definition Characterization of the Persistence and Perturbation of the HIV Reservoir: Project 3P01AI169768 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI Athe M. Tsibris · 2022 to 2026
$10.1M
Multidisciplinary HIV Training ProgramT32AI007387 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Daniel R. Kuritzkes · 1990 to 2026
$8.8M
HIV Reservoir Ecology of Viral Remission (PTC)R01AI150396 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI LI, JONATHAN · 2020 to 2025
$5.4M
Antibody dependent cellular cytotoxicity and HIV-1 mother to child transmissionR01AI172843 · NIAID · BOSTON MEDICAL CENTER · PI SAGAR, MANISH · 2022 to 2025
$3.5M
HIV-1 mucosal transmission and persistenceK24AI145661 · NIAID · BOSTON MEDICAL CENTER · PI SAGAR, MANISH · 2019 to 2023
$908k
HIV Reservoir Ecology of Viral Remission (PTC)R37AI150396 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI Jonathan Li · 2026 to 2026
$868k
NIAID NIH HHS K24 AI145661NIAID NIH HHS P01 AI169768NIAID NIH HHS P30 AI042853NIAID NIH HHS R01 AI150396NIAID NIH HHS R01 AI172843NIAID NIH HHS R21 AI155152NIAID NIH HHS R37 AI150396NIAID NIH HHS T32 AI007387NIAID NIH HHS UM1 AI068634NIAID NIH HHS UM1 AI068636NIAID NIH HHS UM1 AI106701NIAID NIH HHS UM1 AI164560
6 · The paper itself

Abstract

Early initiation of antiretroviral therapy (ART) alters viral rebound kinetics after analytic treatment interruption (ATI) and may play a role in promoting HIV-1 remission. Autologous neutralizing antibodies (aNAbs) represent a key adaptive immune response in people living with HIV-1. We aimed to investigate the role of aNAbs in shaping post-ATI HIV-1 rebound variants. We performed single-genome amplification of HIV-1

Indexed as

Antibodies, NeutralizingHIV InfectionsAnti-Retroviral AgentsHIV AntibodiesHumansImmunoglobulin GProvirusesViral LoadAntibodies, NeutralizingAnti-Retroviral AgentsHIV AntibodiesImmunoglobulin G

Identifiers

PMID37163616
PMCPMC10576978
OpenAlexW4376111076

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.