Evidence map›Paper›PMID 37163287›Full record

ArticleFEBS open bio2023

High growth hormone serum partially protects mice against Trypanosoma cruzi infection.

Patricia Mora-Criollo, Reetobrata Basu, Yanrong Qian, Kevin Funk, Stephen Bell, Jonathan A Young, Edward O List, Jaime A Costales, Jaime Guevara-Aguirre, Mario J Grijalva and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS open bio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Patricia Mora-CriolloDepartment of Biomedical Sciences, Infectious and Tropical Disease Institute, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA.ORCID 0000-0003-4198-8011
Reetobrata BasuEdison Biotechnology Institute, Ohio University, Athens, OH, USA.ORCID 0000-0001-8415-1356
Yanrong QianEdison Biotechnology Institute, Ohio University, Athens, OH, USA.
Kevin FunkEdison Biotechnology Institute, Ohio University, Athens, OH, USA.
Stephen BellEdison Biotechnology Institute, Ohio University, Athens, OH, USA.
Jonathan A YoungEdison Biotechnology Institute, Ohio University, Athens, OH, USA.ORCID 0000-0003-1770-1391
Edward O ListEdison Biotechnology Institute, Ohio University, Athens, OH, USA.
Jaime A CostalesCentro de Investigación para la Salud en América Latina, Escuela de Ciencias Biológicas, Facultad de Ciencias Exactas y Naturales, Pontificia Universidad Católica del Ecuador, Quito, Ecuador.
Jaime Guevara-AguirreColegio de Ciencias de la Salud, Universidad San Francisco de Quito, Ecuador.
Mario J GrijalvaDepartment of Biomedical Sciences, Infectious and Tropical Disease Institute, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA.ORCID 0000-0003-1964-1425
John J KopchickEdison Biotechnology Institute, Ohio University, Athens, OH, USA.ORCID 0000-0003-4561-2177

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chagas disease (CD) is one of the most devasting parasitic diseases in the Americas, affecting 7-8 million people worldwide. In vitro and in vivo experiments have demonstrated that growth hormone (GH) serum levels decrease as CD progresses. Interestingly, inactivating mutations in the GH receptor in humans result in Laron syndrome (LS), a clinical entity characterized by increased serum levels of GH and decreased insulin growth factor-1 (IGF-1). The largest cohort of LS subjects lives in the southern provinces of Ecuador. Remarkably, no clinical CD cases have been reported in these individuals despite living in highly endemic areas. In the current ex vivo study, we employed serum from GHR

Indexed as

Chagas DiseaseInsulin-Like Growth Factor IAnimalsCattleGrowth HormoneHumansMiceMice, TransgenicReceptors, SomatotropinGrowth HormoneInsulin-Like Growth Factor IReceptors, SomatotropinbGHChagas diseaseGHR−/− micegrowth hormoneLaron syndromeTrypanosoma cruzi

Identifiers

PMID37163287
PMCPMC10315831

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.