Evidence map›Paper›PMID 37163097›Full record

ArticlebioRxiv : the preprint server for biology2023

Neural stem and progenitor cells support and protect adult hippocampal function via vascular endothelial growth factor secretion.

Jiyeon K Denninger, Lisa N Miller, Ashley E Walters, Manal Hosawi, Gwendolyn Sebring, Joshua D Rieskamp, Tianli Ding, Raina Rindani, Kelly S Chen, Sakthi Senthilvelan and 4 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Jiyeon K DenningerDepartment of Psychology, The Ohio State University, Columbus, OH, USA.
Lisa N MillerDepartment of Psychology, The Ohio State University, Columbus, OH, USA.
Ashley E WaltersDepartment of Psychology, The Ohio State University, Columbus, OH, USA.
Manal HosawiDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Gwendolyn SebringDepartment of Psychology, The Ohio State University, Columbus, OH, USA.
Joshua D RieskampDepartment of Psychology, The Ohio State University, Columbus, OH, USA.
Tianli DingDepartment of Psychology, The Ohio State University, Columbus, OH, USA.
Raina RindaniDepartment of Psychology, The Ohio State University, Columbus, OH, USA.
Kelly S ChenDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Sakthi SenthilvelanDepartment of Psychology, The Ohio State University, Columbus, OH, USA.
Abigail VolkDepartment of Psychology, The Ohio State University, Columbus, OH, USA.
Fangli ZhaoDepartment of Neuroscience, The Ohio State University, Columbus, OH, USA.
Candice AskwithDepartment of Neuroscience, The Ohio State University, Columbus, OH, USA.
Elizabeth D KirbyDepartment of Psychology, The Ohio State University, Columbus, OH, USA.
The Ohio State University · USStanford University · USCincinnati Health Department · US

Funding

Regulation of adult hippocampal function by the neural stem and progenitor cell secretomeR01NS124775 · NINDS · OHIO STATE UNIVERSITY · PI Elizabeth Diana Kirby · 2022 to 2026
$2.0M
Ohio State University Neuroscience Center Core-Core EP30NS104177 · NINDS · OHIO STATE UNIVERSITY · PI BROWN, ANTHONY · 2017 to 2020
$1.9M
Regulation and regeneration of hippocampal plasticity by neural progenitor cellsR00NS089938 · NINDS · OHIO STATE UNIVERSITY · PI KIRBY, ELIZABETH DIANA · 2017 to 2019
$747k
NINDS NIH HHS P30 NS104177NINDS NIH HHS R00 NS089938NINDS NIH HHS R01 NS124775
6 · The paper itself

Abstract

Adult neural stem and progenitor cells (NSPCs) reside in the dentate gyrus (DG) of the hippocampus throughout the lifespan of most mammalian species. In addition to generating new neurons, NSPCs may alter their niche via secretion of growth factors and cytokines. We recently showed that adult DG NSPCs secrete vascular endothelial growth factor (VEGF), which is critical for maintaining adult neurogenesis. Here, we asked whether NSPC-derived VEGF alters hippocampal function independent of adult neurogenesis. We found that loss of NSPC-derived VEGF acutely impaired hippocampal memory, caused neuronal hyperexcitability and exacerbated excitotoxic injury. We also found that NSPCs generate substantial proportions of total DG VEGF and VEGF disperses broadly throughout the DG, both of which help explain how this anatomically-restricted cell population could modulate function broadly. These findings suggest that NSPCs actively support and protect DG function via secreted VEGF, thereby providing a non-neurogenic functional dimension to endogenous NSPCs.

Indexed as

Adult neural stem cellexcitotoxicityhippocampusneurogenesissecretomeVEGF

Identifiers

PMID37163097
PMCPMC10168272
OpenAlexW4366813882

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.