Evidence map›Paper›PMID 37163092›Full record

ArticleResearch square2023

Chronic viral infection compromises the quality of circulating mucosal-invariant T cells and follicular T helper cells via expression of both activating and inhibitory receptors.

Jaisheela Vimali, Yean Kong Yong, Amudhan Murugesan, Hong Yien Tan, Ying Zhang, Rajeev Ashwin, Sivadoss Raju, Pachamuthu Balakrishnan, Marie Larsson, Vijayakumar Velu and 1 more

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 4 countries.

Jaisheela VimaliDepartment of Life Sciences, Central University of Tamil Nadu, Thiruvarur, India.ORCID 0009-0002-1607-1658
Yean Kong YongXiamen University, Sepang, Malaysia.ORCID 0000-0002-8409-6251
Amudhan MurugesanDepartment of Microbiology, Government Theni Medical College and Hospital, Theni, India.ORCID 0000-0003-4713-2927
Hong Yien TanXiamen University, Sepang, Malaysia.ORCID 0000-0002-0415-7270
Ying ZhangXiamen University, Sepang, Malaysia.
Rajeev AshwinDepartment of Life Sciences, Central University of Tamil Nadu, Thiruvarur, India.
Sivadoss RajuDirectorate of Public Health and Preventive Medicine, Chennai, India.ORCID 0000-0002-0524-2979
Pachamuthu BalakrishnanCentre for Infectious Diseases, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, India.ORCID 0000-0002-1710-9155
Marie LarssonDivision of Molecular Medicine and Virology, Department of Biomedical and Clinical Sciences, Linköping University, 58185 Linköping, Sweden.ORCID 0000-0002-4524-0177
Vijayakumar VeluDepartment of Pathology and Laboratory Medicine, Emory National Primate Research Center, Emory University, Atlanta GA, United States.ORCID 0000-0003-4238-1924
Esaki M ShankarDepartment of Life Sciences, Central University of Tamil Nadu, Thiruvarur, India.ORCID 0000-0002-7866-9818
Central University of Tamil Nadu · INXiamen University Malaysia · MYEmory University · USLinköping University · SESaveetha University · IN

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0M
Innate NKT Cells in HIV InfectionR37AI052731 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NIXON, DOUGLAS F · 2007 to 2016
$3.1M
Innate NKT Cells in HIV InfectionR01AI052731 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NIXON, DOUGLAS F · 2002 to 2006
$2.1M
NIAID NIH HHS P30 AI050409NIAID NIH HHS R01 AI052731NIAID NIH HHS R37 AI052731NIH HHS P51 OD011132
6 · The paper itself

Abstract

Chronic viral infection results in impaired immune responses rendering viral persistence. Here, we investigated the role of immune activation and compared the quality of T-cell responses in chronic HBV, HCV, and HIV infections. Cytokines were measured using a commercial Bio-plex Pro Human Cytokine Grp I Panel 17-plex kit (BioRad, Hercules, CA, USA). Inflammation was assessed by measuring an array of plasma cytokines, and peripheral CD4

Indexed as

HBVHIVMAIT cellsPD-1T cell exhaustion

Identifiers

PMID37163092
PMCPMC10168456
OpenAlexW4367185410

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.