Evidence map›Paper›PMID 37163091›Full record

ArticlebioRxiv : the preprint server for biology2023

Alpha Synuclein Modulates Mitochondrial Ca

Meraj Ramezani, Alice Wagenknecht-Wiesner, Tong Wang, David A Holowka, David Eliezer, Barbara A Baird

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Meraj RamezaniDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853.
Alice Wagenknecht-WiesnerDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853.
Tong WangDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853.
David A HolowkaDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853.
David EliezerDepartment of Biochemistry, Weill Cornell Medicine, New York, NY 10065.
Barbara A BairdDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853.
Cornell University · US

Funding

Structure and Function of Protein Disorder in Membrane Trafficking and OrganizationR35GM136686 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI ELIEZER, DAVID · 2020 to 2025
$4.5M
High Resolution Characterization of Receptor Signaling and RegulationR01GM117552 · NIGMS · CORNELL UNIVERSITY · PI BAIRD, BARBARA A, HOLOWKA, DAVID A · 2016 to 2023
$3.2M
Zeiss LSM710 Confocal Microscope for Shared Imaging FacilityS10RR025502 · NCRR · CORNELL UNIVERSITY · PI WILLIAMS, REBECCA M · 2009 to 2009
$500k
NCRR NIH HHS S10 RR025502NIGMS NIH HHS R01 GM117552NIGMS NIH HHS R35 GM136686
6 · The paper itself

Abstract

Alpha synuclein (a-syn) is an intrinsically disordered protein prevalent in neurons, and aggregated forms are associated with synucleinopathies including Parkinson' disease (PD). Despite the biomedical importance and extensive studies, the physiological role of a-syn and its participation in etiology of PD remain uncertain. We showed previously in model RBL cells that a-syn colocalizes with mitochondrial membranes, depending on formation of N-terminal helices and increasing with mitochondrial stress.

Identifiers

PMID37163091
PMCPMC10168219
OpenAlexW4366823404

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.