ArticlebioRxiv : the preprint server for biology2023
Gut microbiota and metabolites drive chronic sickle cell disease pain.
Katelyn E Sadler, Samantha N Atkinson, Vanessa L Ehlers, Tyler B Waltz, Michael Hayward, Dianise M Rodríguez García, Nita H Salzman, Cheryl L Stucky, Amanda M Brandow
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 9 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
9 authors at 2 institutions in 1 country.
Katelyn E SadlerDepartment of Neuroscience, The University of Texas at Dallas; Richardson, TX.
Samantha N AtkinsonCenter for Microbiome Research, Medical College of Wisconsin; Milwaukee, WI.
Vanessa L EhlersDepartment of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin; Milwaukee, WI.
Tyler B WaltzDepartment of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin; Milwaukee, WI.
Michael HaywardCenter for Microbiome Research, Medical College of Wisconsin; Milwaukee, WI.
Dianise M Rodríguez GarcíaDepartment of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin; Milwaukee, WI.
Nita H SalzmanCenter for Microbiome Research, Medical College of Wisconsin; Milwaukee, WI.
Cheryl L StuckyDepartment of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin; Milwaukee, WI.
Amanda M BrandowDepartment of Pediatrics, Section of Hematology/Oncology/Bone Marrow Transplantation, Medical College of Wisconsin; Milwaukee, WI.
Medical College of Wisconsin · USThe University of Texas at Dallas · US
Funding
Nociceptive Mechanisms Underlying Sickle Cell PainR01NS070711 · NINDS · MEDICAL COLLEGE OF WISCONSIN · PI Bonnie N Dittel, Cheryl Louise Stucky · 2009 to 2026
$8.7MMedical Scientist Training ProgramT32GM080202 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI BARBIERI, JOSEPH T, SALZMAN, NITA H · 2010 to 2024
$5.7MInvestigating the role of the microbiome and inflammation in acute and chronic pain in patients with sickle cell diseaseR01HL142657 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI BRANDOW, AMANDA M · 2018 to 2022
$3.7MIntestinal Enterococcal Dynamics: Modeling Host-Commensal and Host-Pathogen InteractionsR35GM122503 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI SALZMAN, NITA H · 2017 to 2021
$2.7MSickle cell disease gut dysbiosis effects on CNS pain processingR00HL155791 · NHLBI · UNIVERSITY OF TEXAS DALLAS · PI SADLER, KATELYN · 2023 to 2025
$747kSickle cell disease gut dysbiosis effects on CNS pain processingK99HL155791 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI SADLER, KATELYN · 2021 to 2022
$230kNHLBI NIH HHS K99 HL155791NHLBI NIH HHS R00 HL155791NHLBI NIH HHS R01 HL142657NIGMS NIH HHS R35 GM122503NIGMS NIH HHS T32 GM080202NINDS NIH HHS R01 NS070711
6 · The paper itselfAbstract
Pain is a debilitating symptom and leading reason for hospitalization of individuals with sickle cell disease. Chronic sickle cell pain is poorly managed because the biological basis is not fully understood. Using transgenic sickle cell mice and fecal material transplant, we determined that the gut microbiome drives persistent sickle cell pain. In parallel patient and mouse analyses, we identified bilirubin as one metabolite that induces sickle cell pain by altering vagus nerve activity. Furthermore, we determined that decreased abundance of the gut bacteria
Identifiers
PMID37163080
PMCPMC10168372
OpenAlexW4367296968
What OpenQuestion holds
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