Evidence map›Paper›PMID 37163061›Full record

ArticlebioRxiv : the preprint server for biology2023

A Zika virus protein expression screen in

Nichole Link, J Michael Harnish, Brooke Hull, Shelley Gibson, Miranda Dietze, Uchechukwu E Mgbike, Silvia Medina-Balcazar, Priya S Shah, Shinya Yamamoto

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Nichole LinkDepartment of Neurobiology, University of Utah, Salt Lake City, UT, 84112, USA.
J Michael HarnishDepartment of Molecular and Human Genetics, BCM, Houston, TX, 77030, USA.
Brooke HullDepartment of Molecular and Human Genetics, BCM, Houston, TX, 77030, USA.
Shelley GibsonDepartment of Molecular and Human Genetics, BCM, Houston, TX, 77030, USA.
Miranda DietzeDepartment of Neurobiology, University of Utah, Salt Lake City, UT, 84112, USA.
Uchechukwu E MgbikeDepartment of Neurobiology, University of Utah, Salt Lake City, UT, 84112, USA.
Silvia Medina-BalcazarDepartment of Molecular and Human Genetics, BCM, Houston, TX, 77030, USA.
Priya S ShahDepartment of Chemical Engineering, Department of Microbiology and Molecular Genetics, University of California, Davis, CA, 95616, USA.
Shinya YamamotoDepartment of Molecular and Human Genetics, BCM, Houston, TX, 77030, USA.
Neurological Research Institute · USUniversity of Utah · USBaylor College of Medicine · USHoward Hughes Medical Institute · USUniversity of California, Davis · US

Funding

Initiative for Maximizing Student Development (IMSD) ProgramR25GM056929 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI PEREIRA, FRED A · 1998 to 2023
$12.4M
Preclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MIRJANA MALETIC-SAVATIC · 2020 to 2026
$9.9M
Steps towards a paternal gene activation therapy for Angelman syndromeU54HD083092 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI NELSON, DAVID LOREN, NEUL, JEFFREY L · 2014 to 2019
$7.8M
YEARS 19 - 23: BCM POST-BACCALAUREATE RESEARCH EDUCATION PROGRAMR25GM069234 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI PEREIRA, FRED A · 2003 to 2024
$7.5M
Molecular mechanisms linking viral replication and neuropathogenesisR01AI170857 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Priya Shirish Shah · 2023 to 2026
$2.1M
Molecular mechanisms linking viral replication and neuropathogenesisR56AI170857 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SHAH, PRIYA SHIRISH · 2022 to 2022
$528k
NIAID NIH HHS R01 AI170857NIAID NIH HHS R56 AI170857NICHD NIH HHS P50 HD103555NICHD NIH HHS U54 HD083092NIGMS NIH HHS R25 GM056929NIGMS NIH HHS R25 GM069234
6 · The paper itself

Abstract

In the past decade, Zika virus (ZIKV) emerged as a global public health concern. While adult infections are typically mild, maternal infection can lead to adverse fetal outcomes. Understanding how ZIKV proteins disrupt development can provide insights into the molecular mechanisms of symptoms caused by this virus including microcephaly. In this study, we generated a toolkit to ectopically express Zika viral proteins

Identifiers

PMID37163061
PMCPMC10168400
OpenAlexW4367394167

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.