ArticlemedRxiv : the preprint server for health sciences2023
Creating the Pick's disease International Consortium: Association study of
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141 authors at 20 institutions in 15 countries.
Rebecca R ValentinoDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
William J ScottonDementia Research Centre, Department of Neurodegenerative Disease, University College London, Queen Square Institute of Neurology, London, UK.
Shanu F RoemerDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Tammaryn LashleyQueen Square Brain Bank for Neurological Disorders, University College London, Queen Square Institute of Neurology London, UK.
Michael G HeckmanDivision of Clinical Trials and Biostatistics, Mayo Clinic, Jacksonville, FL 32224, USA.
Maryam ShoaiDepartment of Neurodegenerative Disease, University College London, Queen Square Institute of Neurology, London, UK.
Alejandro Martinez-CarrascoDepartment of Clinical and Movement Neurosciences, University College London, Queen Square Institute of Neurology, London, UK.
Nicole TamvakaDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Ronald L WaltonDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Matthew C BakerDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Hannah L MacphersonDepartment of Neurodegenerative Disease, University College London, Queen Square Institute of Neurology, London, UK.
Raquel RealDepartment of Clinical and Movement Neurosciences, University College London, Queen Square Institute of Neurology, London, UK.
Alexandra I Soto-BeasleyDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Kin MokDepartment of Neurodegenerative Disease, University College London, Queen Square Institute of Neurology, London, UK.
Tamas ReveszQueen Square Brain Bank for Neurological Disorders, University College London, Queen Square Institute of Neurology London, UK.
Thomas T WarnerQueen Square Brain Bank for Neurological Disorders, University College London, Queen Square Institute of Neurology London, UK.
Zane JaunmuktaneQueen Square Brain Bank for Neurological Disorders, University College London, Queen Square Institute of Neurology London, UK.
Bradley F BoeveDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Elizabeth A ChristopherDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Michael DeTureDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Ranjan DuaraWien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center Miami Beach, FL.
Neill R Graff-RadfordDepartment of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.
Keith A JosephsDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
David S KnopmanDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Shunsuke KogaDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Melissa E MurrayDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Kelly E LyonsUniversity of Kansas Medical Center, Parkinson's Disease & Movement Disorder Division, Kansas City, KS. 66160.
Rajesh PahwaUniversity of Kansas Medical Center, Parkinson's Disease & Movement Disorder Division, Kansas City, KS. 66160.
Joseph E ParisiLaboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.
Ronald C PetersenDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Jennifer WhitwellDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Lea T GrinbergDepartment of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.
Bruce MillerDepartment of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.
Athena SchlerethDepartment of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.
William W SeeleyDepartment of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.
Salvatore SpinaDepartment of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.
Murray GrossmanDepartment of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
David J IrwinDepartment of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Edward B LeeDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
EunRan SuhDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
John Q TrojanowskiDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Vivianna M Van DeerlinDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
David A WolkDepartment of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Theresa R ConnorsNeuropathology Service, C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Patrick M DooleyNeuropathology Service, C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Matthew P FroschNeuropathology Service, C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Derek H OakleyNeuropathology Service, C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Iban AldecoaPathology, BDC, Hospital Clinic de Barcelona, Barcelona, Spain.
Mircea BalasaAlzheimer's Disease and other Cognitive Disorders Unit, Neurology Department, Hospital Clinic, Barcelona, Spain.
Ellen GelpiDivision of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, Vienna, Austria.
Sergi Borrego-ÉcijaAlzheimer's Disease and other Cognitive Disorders Unit, Neurology Department, Hospital Clinic, Barcelona, Spain.
Rosa Maria de Eugenio HuélamoHospital de Palamós, Carrer Hospital, 36, 17230 Palamós, Girona, Spain.
Jordi Gascon-BayarriServei de Neurologia, Hospital Universitari de Bellvitge. Institut d'Investigació Biomèdica de Bellvitge (Idibell). L'Hospitalet de Llobregat, Spain.
Raquel Sánchez-ValleAlzheimer's Disease and other Cognitive Disorders Unit, Neurology Department, Hospital Clinic, Barcelona, Spain.
Pilar Sanz-CartagenaHospital de Mataro, Carr. de Cirera, 230, 08304 Mataró, Barcelona, Spain.
Gerard Piñol-RipollUnitat Trastorns Cognitius (Cognitive Disorders Unit), Clinical Neuroscience Research, IRBLleida, Santa Maria University Hospital, Lleida, Spain.
Laura Molina-PorcelNeurological Tissue Bank, Biobanc-Hospital Clínic-FRCB-IDIBAPS, Barcelona, Spain.
Eileen H BigioMesulam Center for Cognitive Neurology & Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Margaret E FlanaganMesulam Center for Cognitive Neurology & Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Tamar GefenMesulam Center for Cognitive Neurology & Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Emily J RogalskiMesulam Center for Cognitive Neurology & Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Sandra WeintraubMesulam Center for Cognitive Neurology & Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Javier Redding-OchoaJohns Hopkins School of Medicine, Baltimore, MD, USA.
Koping ChangJohns Hopkins School of Medicine, Baltimore, MD, USA.
Juan C TroncosoJohns Hopkins School of Medicine, Baltimore, MD, USA.
Stefan ProkopFixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA.
Kathy L NewellDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
Bernardino GhettiDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
Matthew JonesCerebral Function Unit, Manchester Centre for Clinical Neurosciences, Salford Royal NHS Foundation Trust, UK.
Anna RichardsonCerebral Function Unit, Manchester Centre for Clinical Neurosciences, Salford Royal NHS Foundation Trust, UK.
Andrew C RobinsonDivision of Neuroscience, Faculty of Biology, Medicine and Health, School of Biological Sciences, The University of Manchester, Salford Royal Hospital, Salford, M6 8HD, UK.
Federico RoncaroliDivision of Neuroscience, Faculty of Biology, Medicine and Health, School of Biological Sciences, The University of Manchester, Salford Royal Hospital, Salford, M6 8HD, UK.
Julie SnowdenCerebral Function Unit, Manchester Centre for Clinical Neurosciences, Salford Royal NHS Foundation Trust, UK.
Kieren AllinsonHistopathology Box 235 Cambridge University Hospital NHS Foundation Trust, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0QQ.
Oliver GreenHistopathology Box 235 Cambridge University Hospital NHS Foundation Trust, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0QQ.
James B RoweCambridge University Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, Cambridge, UK.
Poonam SinghHistopathology Box 235 Cambridge University Hospital NHS Foundation Trust, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0QQ.
Thomas G BeachCivin Laboratory of Neuropathology, Banner Sun Health Research Institute, Sun City, AZ 85351, USA.
Geidy E SerranoCivin Laboratory of Neuropathology, Banner Sun Health Research Institute, Sun City, AZ 85351, USA.
Xena E FlowersTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.
James E GoldmanDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Allison C HeapsTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.
Sandra P LeskinenTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.
Andrew F TeichDepartment of Pathology and Cell Biology, Columbia University, New York, NY, USA.
Sandra E BlackDepartment of Medicine, Division of Neurology, Sunnybrook Health Sciences Centre and University of Toronto, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute.
Julia L KeithLaboratory Medicine and Molecular Diagnostics, Sunnybrook Health Sciences Centre, and Laboratory Medicine and Pathobiology, University of Toronto.
Mario MasellisDepartment of Medicine, Division of Neurology, Sunnybrook Health Sciences Centre and University of Toronto, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute.
Istvan BodiClinical Neuropathology Department, King's College Hospital NHS Foundation Trust, London, UK.
Andrew KingClinical Neuropathology Department, King's College Hospital NHS Foundation Trust, London, UK.
Safa-Al SarrajClinical Neuropathology Department, King's College Hospital NHS Foundation Trust, London, UK.
Claire TroakesLondon Neurodegenerative Diseases Brain Bank, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Glenda M HallidayUniversity of Sydney Brain and Mind Centre and Faculty of Medicine and Health School of Medical Sciences.
John R HodgesUniversity of Sydney Brain and Mind Centre and Faculty of Medicine and Health School of Medical Sciences.
Jillian J KrilUniversity of Sydney Faculty of Medicine and Health School of Medical Sciences.
John B KwokUniversity of Sydney Brain and Mind Centre and Faculty of Medicine and Health School of Medical Sciences.
Olivier PiguetUniversity of Sydney Brain and Mind Centre and Faculty of Science School of Psychology.
Marla GearingDept. of Pathology and Laboratory Medicine, Dept. of Neurology, and Goizueta Alzheimer's Disease Center Brain Bank; Emory University School of Medicine, Atlanta, GA USA.
Thomas ArzbergerDepartment of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilians-University Munich, Germany.
Sigrun RoeberCenter for Neuropathology and Prion Research, Ludwig-Maximilians-University Munich, Germany.
Johannes AttemsNewcastle Brain Tissue Resource, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK.
Christopher M MorrisNewcastle Brain Tissue Resource, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK.
Alan J ThomasNewcastle Brain Tissue Resource, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK.
Bret M EversUniversity of Texas Southwestern Medical Center, Dallas, TX 75390.
Charles L WhiteUniversity of Texas Southwestern Medical Center, Dallas, TX 75390.
Naguib MechawarDouglas Hospital Research Centre.
Anne A SiebenLaboratory of Neurology, Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Patrick P CrasLaboratory of Neurology, Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Bart B De VilLaboratory of Neurology, Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Peter Paul P P De DeynLaboratory of Neurochemistry and Behavior, Experimental Neurobiology Unit, University of Antwerp, Universiteitsplein 1, 2610 Antwerpen, Belgium.
Charles DuyckaertsLaboratoire de Neuropathologie Escourolle, Hôpital de la Salpêtrière, AP-HP, & Alzheimer Prion Team, ICM, 47 Bd de l'Hôpital, 75651 CEDEX 13 Paris, France.
Isabelle Le BerInserm U1127, CNRS UMR 7225, Sorbonne Université, Paris Brain Institute (ICM), Hôpital Pitié-Salpêtrière, Paris, France.
Danielle SeiheanLaboratoire de Neuropathologie Escourolle, Hôpital de la Salpêtrière, AP-HP, & ICM, 47 Bd de l'Hôpital, 75651 CEDEX 13 Paris, France.
Sabrina Turbant-LeclereInserm U1127, CNRS UMR 7225, Sorbonne Université, Paris Brain Institute (ICM) Hôpital Pitié-Salpêtrière, Paris, France.
Ian R MacKenzieDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC Canada V6T 2B5.
Catriona McLeanDepartment of Anatomical Pathology Alfred Heath, Melbourne, Victoria, 3004, Australia.
Matthew D CykowskiDepartment of Pathology and Genomic Medicine, Houston Methodist Research Institute and Weill Cornell Medicine, Houston, TX.
John F ErvinDepartment of Neurology, Duke University Medical Center, Durham, USA.
Shih-Hsiu J WangDepartment of Neurology, Duke University Medical Center, Durham, USA.
Caroline GraffDivision for Neurogeriatrics, Centre for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Inger NennesmoDept of laboratory Medicine Huddinge Karolinska Institutet, Stockholm Sweden.
Rashed M NagraHuman Brain and Spinal Fluid Resource Center, Brentwood Biomedical Research Institute, Los Angeles, CA, United States.
James RiehlUCLA - Sepulveda, Los Angeles, CA.
Gabor G KovacsTanz Centre for Research in Neurodegenerative Disease (CRND) and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Giorgio GiacconeFondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Benedetta NacmiasDepartment of Neuroscience, Psychology, Drug Research and Child Health University of Florence, Florence, Italy.
Manuela NeumannMolecular Neuropathology of Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
Lee-Cyn AngDepartment of Pathology and Laboratory Medicine, London Health Sciences Centre, London, ON, Canada.
Elizabeth C FingerDepartment of Clinical Neurological Sciences, Western University, London, ON, Canada.
Cornelis BlauwendraatLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Mike A NallsLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Andrew B SingletonLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Dan VitaleLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Cristina CunhaLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Agostinho CarvalhoLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Zbigniew K WszolekDepartment of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.
Huw R MorrisDepartment of Clinical and Movement Neurosciences, University College London, Queen Square Institute of Neurology, London, UK.
Rosa RademakersVIBUAntwerp Center for Molecular Neurology, University of Antwerp, Antwerp 2610, Belgium.
John A HardyUK Dementia Research Institute at UCL, London, UK.
Dennis W DicksonDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Jonathan D RohrerDementia Research Centre, Department of Neurodegenerative Disease, University College London, Queen Square Institute of Neurology, London, UK.
Owen A RossDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Mayo Clinic in Florida · USNational Hospital for Neurology and Neurosurgery · GBUniversity of Pennsylvania · USColumbia University · USHospital Clínic de Barcelona · ESMayo Clinic · USNorthwestern University · USThe University of Sydney · AUUniversity of Antwerp · BEUniversity of California, San Francisco · USHarvard University · USKing's College London · GBNational Institutes of Health · USCambridge University Hospitals NHS Foundation Trust · GBJohns Hopkins University · USNewcastle University · GBSalford Royal NHS Foundation Trust · GBSunnybrook Health Science Centre · CAAssistance Publique – Hôpitaux de Paris · FRBanner Sun Health Research Institute · US
Funding
Technology and Remote Assessment CoreU19AG063911 · NIA · MAYO CLINIC ROCHESTER · PI ADAM L. BOXER, Bradley F Boeve · 2019 to 2026
$120.9MVascular Structure and Function in Cognitive AgingP01AG003949 · NIA · YESHIVA UNIVERSITY · PI Cuiling Wang · 1985 to 2026
$73.9MEarly Onset AD Consortium - the LEAD Study (LEADS)U01AG057195 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI APOSTOLOVA, LIANA G, CARRILLO, MARIA C · 2018 to 2023
$70.3MTDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2MSUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6MProject: Predicting PhenoconversionU19AG071754 · NIA · WASHINGTON UNIVERSITY · PI Erik Kent St. Louis · 2021 to 2026
$41.2MResearch Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3MTransgenic Mouse Models of Tau PathologiesP01AG017586 · NIA · UNIVERSITY OF PENNSYLVANIA · PI LEE, VIRGINIA M · 2000 to 2021
$37.3MResearch Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI STEVEN E ARNOLD · 2019 to 2026
$36.5MUPenn ADCC Biomarker CoreP30AG010124 · NIA · UNIVERSITY OF PENNSYLVANIA · PI DETRE, JOHN A · 1991 to 2020
$35.1MResearch Education ComponentP30AG062677 · NIA · MAYO CLINIC ROCHESTER · PI NILUFER ERTEKIN-TANER · 2019 to 2026
$33.5MResearch Education ComponentP30AG019610 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI REIMAN, ERIC MICHAEL · 2001 to 2020
$32.5MMedical Research Council MR/J009482/1Medical Research Council MR/M008525/1Medical Research Council MR/M023664/1Medical Research Council MR/T046015/1NIA NIH HHS K08 AG052648NIA NIH HHS K08 AG065463NIA NIH HHS K24 AG053435NIA NIH HHS P01 AG003949NIA NIH HHS P01 AG017586NIA NIH HHS P01 AG019724NIA NIH HHS P01 AG066597NIA NIH HHS P30 AG010124NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG013854NIA NIH HHS P30 AG019610NIA NIH HHS P30 AG062421NIA NIH HHS P30 AG062677NIA NIH HHS P30 AG066462NIA NIH HHS P30 AG066511NIA NIH HHS P30 AG066546NIA NIH HHS P30 AG072958NIA NIH HHS P30 AG072977NIA NIH HHS P30 AG072979NIA NIH HHS P30 AG072980NIA NIH HHS P50 AG023501NIA NIH HHS R01 AG037491NIA NIH HHS R01 AG060477NIA NIH HHS R01 AG062566NIA NIH HHS R01 AG077444NIA NIH HHS U01 AG006786NIA NIH HHS U01 AG057195NIA NIH HHS U19 AG063911NIA NIH HHS U19 AG071754NIDCD NIH HHS R01 DC008552NIDCD NIH HHS R01 DC014942NINDS NIH HHS P50 NS072187NINDS NIH HHS R01 NS075075NINDS NIH HHS R01 NS078086NINDS NIH HHS R01 NS089757NINDS NIH HHS R01 NS109260NINDS NIH HHS R01 NS112153NINDS NIH HHS RF1 NS112153NINDS NIH HHS RF1 NS118584NINDS NIH HHS RF1 NS120992NINDS NIH HHS U01 NS100620NINDS NIH HHS U24 NS072026NINDS NIH HHS U54 NS100693NINDS NIH HHS U54 NS110435NINDS NIH HHS UG3 NS104095Wellcome Trust
Abstract
Background: Pick's disease (PiD) is a rare and predominantly sporadic form of frontotemporal dementia that is classified as a primary tauopathy. PiD is pathologically defined by argyrophilic inclusion Pick bodies and ballooned neurons in the frontal and temporal brain lobes. PiD is characterised by the presence of Pick bodies which are formed from aggregated, hyperphosphorylated, 3-repeat tau proteins, encoded by the Methods: We established the Pick's disease International Consortium (PIC) and collected 338 (60.7% male) pathologically confirmed PiD brains from 39 sites worldwide. 1,312 neurologically healthy clinical controls were recruited from Mayo Clinic Jacksonville, FL (N=881) or Rochester, MN (N=431). For the primary analysis, subjects were directly genotyped for Findings: Our primary analysis found that the Interpretation: The PIC represents the first opportunity to perform relatively large-scale studies to enhance our understanding of the pathobiology of PiD. This study demonstrates that in contrast to its protective role in 4R tauopathies, the
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