Evidence map›Paper›PMID 37162952›Full record

ArticlebioRxiv : the preprint server for biology2023

Nuclear receptor signaling via NHR-49/MDT-15 regulates stress resilience and proteostasis in response to reproductive and metabolic cues.

Ambre J Sala, Rogan A Grant, Ghania Imran, Claire Morton, Renee M Brielmann, Laura C Bott, Jennifer Watts, Richard I Morimoto

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Ambre J SalaDepartment of Molecular Biosciences, Northwestern University, Evanston IL, USA.
Rogan A GrantDepartment of Molecular Biosciences, Northwestern University, Evanston IL, USA.
Ghania ImranDepartment of Molecular Biosciences, Northwestern University, Evanston IL, USA.
Claire MortonDepartment of Molecular Biosciences, Northwestern University, Evanston IL, USA.
Renee M BrielmannDepartment of Molecular Biosciences, Northwestern University, Evanston IL, USA.
Laura C BottDepartment of Molecular Biosciences, Northwestern University, Evanston IL, USA.
Jennifer WattsSchool of Molecular Biosciences, Washington State University, Pullman WA, USA.
Richard I MorimotoDepartment of Molecular Biosciences, Northwestern University, Evanston IL, USA.
Northwestern University · USWashington State University · US

Funding

The proteasome in aging and neurodegenerative diseaseP01AG054407 · NIA · NORTHWESTERN UNIVERSITY · PI FINLEY, DANIEL J · 2018 to 2022
$14.0M
PREDOCTORAL AND POSTDOCTORAL TRAINING PROGRAM IN AGING AND DEMENTIAT32AG020506 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ROBERT J VASSAR, SANDRA WEINTRAUB · 2002 to 2026
$9.9M
Regulation of Peripheral ProteostasisRF1AG057296 · NIA · NORTHWESTERN UNIVERSITY · PI MORIMOTO, RICHARD I · 2017 to 2017
$3.0M
NIA NIH HHS P01 AG054407NIA NIH HHS RF1 AG057296NIA NIH HHS T32 AG020506
6 · The paper itself

Abstract

The ability to sense and respond to proteotoxic insults declines with age, leaving cells vulnerable to chronic and acute stressors. Reproductive cues modulate this decline in cellular proteostasis to influence organismal stress resilience in

Identifiers

PMID37162952
PMCPMC10168274
OpenAlexW4366998913

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.