Evidence map›Paper›PMID 37162924›Full record

ArticlebioRxiv : the preprint server for biology2023

Tau Filaments from Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex (ALS/PDC) adopt the CTE Fold.

Chao Qi, Bert M Verheijen, Yasumasa Kokubo, Yang Shi, Stephan Tetter, Alexey G Murzin, Asa Nakahara, Satoru Morimoto, Marc Vermulst, Ryogen Sasaki and 9 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 9 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 9 institutions in 5 countries.

Chao QiMRC Laboratory of Molecular Biology, Cambridge, UK.
Bert M VerheijenLeonard Davis School of Gerontology, University of Southern California, Los Angeles, USA.
Yasumasa KokuboGraduate School of Regional Innovation Studies, Mie University, Tsu, Japan.
Yang ShiMRC Laboratory of Molecular Biology, Cambridge, UK.
Stephan TetterMRC Laboratory of Molecular Biology, Cambridge, UK.
Alexey G MurzinMRC Laboratory of Molecular Biology, Cambridge, UK.
Asa NakaharaDepartment of Pathology, Brain Research Institute, Niigata University, Niigata, Japan.
Satoru MorimotoDepartment of Oncologic Pathology, Graduate School of Medicine, Mie University, Tsu, Japan.
Marc VermulstLeonard Davis School of Gerontology, University of Southern California, Los Angeles, USA.
Ryogen SasakiDepartment of Nursing, Suzuka University of Medical Science, Suzuka, Japan.
Eleonora AronicaDepartment of Neuropathology, University of Amsterdam, Amsterdam, The Netherlands.
Yoshifumi HirokawaDepartment of Oncologic Pathology, Graduate School of Medicine, Mie University, Tsu, Japan.
Kiyomitsu OyanagiDepartment of Brain Disease Research, Shinshu University School of Medicine, Matsumoto, Japan.
Akiyoshi KakitaDepartment of Pathology, Brain Research Institute, Niigata University, Niigata, Japan.
Benjamin Ryskeldi-FalconMRC Laboratory of Molecular Biology, Cambridge, UK.
Mari YoshidaDepartment of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Nagakute, Japan.
Masato HasegawaDepartment of Brain and Neuroscience, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Sjors H W ScheresMRC Laboratory of Molecular Biology, Cambridge, UK.
Michel GoedertMRC Laboratory of Molecular Biology, Cambridge, UK.
MRC Laboratory of Molecular Biology · GBMie University · JPNiigata University · JPUniversity of Southern California · USAichi Medical University · JPShinshu University · JPSuzuka University of Medical Science · JPTokyo Metropolitan Institute of Medical Science · JPUniversity of Amsterdam · NL

Funding

Understanding the role of transcription errors in aging and diseaseR01AG054641 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VERMULST, MARC · 2017 to 2021
$1.7M
Medical Research Council MC_UP_1201/25NIA NIH HHS R01 AG054641
6 · The paper itself

Abstract

The amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC) of the island of Guam and the Kii peninsula of Japan is a fatal neurodegenerative disease of unknown cause that is characterised by the presence of abundant filamentous tau inclusions in brains and spinal cords. Here we used electron cryo-microscopy (cryo-EM) to determine the structures of tau filaments from the cerebral cortex of three cases of ALS/PDC from Guam and eight cases from Kii, as well as from the spinal cord of two of the Guam cases. Tau filaments had the chronic traumatic encephalopathy (CTE) fold, with variable amounts of Type I and Type II filaments. Paired helical tau filaments were also found in two Kii cases. We also identified a novel Type III CTE tau filament, where protofilaments pack against each other in an anti-parallel fashion. ALS/PDC is the third known tauopathy with CTE-type filaments and abundant tau inclusions in cortical layers II/III, the others being CTE and subacute sclerosing panencephalitis. Because these tauopathies are believed to have environmental causes, our findings support the hypothesis that ALS/PDC is caused by exogenous factors.

Indexed as

Amyotrophic lateral sclerosis-parkinsonism dementia complex (ALS/PDC)Chronic traumatic encephalopathy tau foldNeurodegenerative diseaseTau filament assembly

Identifiers

PMID37162924
PMCPMC10168338
OpenAlexW4367305546

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.