Evidence map›Paper›PMID 37162918›Full record

ArticlebioRxiv : the preprint server for biology2023

Deciphering the Differential Impact of Thrombopoietin/MPL Signaling on Hematopoietic Stem Cell Function in Bone Marrow and Spleen.

Sandy Lee, Huichun Zhan

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Sandy LeeGraduate Program in Molecular & Cellular Pharmacology, Stony Brook University, Stony Brook, NY.
Huichun ZhanDepartment of Medicine, Stony Brook School of Medicine, Stony Brook, NY.
Stony Brook School · USStony Brook University · US

Funding

Cell Competition in Myeloproliferative NeoplasmsR01CA266294 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI Huichun Zhan · 2022 to 2026
$1.8M
Molecular and Cellular Biology of Megakaryocytes in Normal and Neoplastic HematopoiesisR01HL134970 · NHLBI · STATE UNIVERSITY NEW YORK STONY BROOK · PI ZHAN, HUICHUN · 2017 to 2021
$1.8M
Identification of Therapeutic Targets in the Hematopoietic Vascular NicheI01BX003947 · VA · NORTHPORT VA MEDICAL CENTER · PI ZHAN, HUICHUN · 2020 to 2023
–
Endothelial dysfunction in clonal hematopoiesis and its contribution to cardiovascular complicationsI01BX005584 · VA · NORTHPORT VA MEDICAL CENTER · PI ZHAN, HUICHUN · 2023 to 2025
–
BLRD VA I01 BX003947BLRD VA I01 BX005584NCI NIH HHS R01 CA266294NHLBI NIH HHS R01 HL134970
6 · The paper itself

Abstract

Thrombopoietin (TPO) and its receptor MPL play crucial roles in hematopoietic stem cell (HSC) function and platelet production. However, the precise effects of TPO/MPL signaling on HSC regulation in different hematopoietic niches remain unclear. Here, we investigated the effects of TPO/MPL ablation on marrow and splenic hematopoiesis in TPO

Identifiers

PMID37162918
PMCPMC10168386
OpenAlexW4367319236

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.