Evidence map›Paper›PMID 37162904›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Reconnecting the Hand and Arm to the Brain: Efficacy of Neural Interfaces for Sensorimotor Restoration after Tetraplegia.

Eric Z Herring, Emily L Graczyk, William D Memberg, Robert D Adams, Guadalupe Fernandez Baca-Vaca, Brianna C Hutchison, John T Krall, Benjamin J Alexander, Emily C Conlan, Kenya E Alfaro and 8 more

Registry-linked trialOpen access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03898804 (An Early Feasibility Study to Assess the Effects of the "Reconnecting the Hand and Arm to the Brain), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03898804 narecruitingnot on this map

An Early Feasibility Study to Assess the Effects of the "Reconnecting the Hand and Arm to the Brain (ReHAB)" System

TypeinterventionalSponsorUniversity Hospitals Cleveland Medical CenterRan2019 to 2029Enrolled12ConditionsTetraplegiaArmsBCI and FES
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 8 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Eric Z HerringSchool of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Emily L GraczykSchool of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
William D MembergSchool of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Robert D AdamsLouis Stokes Cleveland Department of Veterans Affairs Medical Center, FES Center of Excellence, Cleveland, Ohio, USA.
Guadalupe Fernandez Baca-VacaThe Neurological Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
Brianna C HutchisonDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
John T KrallDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
Benjamin J AlexanderDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
Emily C ConlanDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
Kenya E AlfaroDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
Preethi R BhatDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
Aaron B Ketting-OlivierDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
Chase A HaddixDepartment of Neuroscience, Lerner Research Institute, The Cleveland Clinic, Cleveland, Ohio, USA.
Dawn M TaylorDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
Dustin J TylerSchool of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Robert F KirschSchool of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
A Bolu AjiboyeSchool of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Jonathan P MillerSchool of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Case Western Reserve University · USThe Neurological Institute · USCleveland Clinic Lerner College of Medicine · US

Funding

Integrated Neural Engineering and Rehabilitation Training ProgramT32EB004314 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI Jeffrey R Capadona, Robert F. Kirsch · 2004 to 2026
$6.1M
Improving intracortical control of reaching after paralysisR01NS119160 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI AJIBOYE, ABIDEMI BOLU, TAYLOR, DAWN MARIE · 2020 to 2024
$2.8M
Restoring High Dimensional Hand Function to Persons with Chronic High TetraplegiaI01RX002654 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI AJIBOYE, ABIDEMI BOLU · 2018 to 2022
–
NIBIB NIH HHS T32 EB004314NINDS NIH HHS R01 NS119160RRD VA I01 RX002654
6 · The paper itself

Abstract

Background: Paralysis after spinal cord injury involves damage to pathways that connect neurons in the brain to peripheral nerves in the limbs. Re-establishing this communication using neural interfaces has the potential to bridge the gap and restore upper extremity function to people with high tetraplegia. Objective: We report a novel approach for restoring upper extremity function using selective peripheral nerve stimulation controlled by intracortical microelectrode recordings from sensorimotor networks, along with restoration of tactile sensation of the hand using intracortical microstimulation. Methods: A right-handed man with motor-complete C3-C4 tetraplegia was enrolled into the clinical trial. Six 64-channel intracortical microelectrode arrays were implanted into left hemisphere regions involved in upper extremity function, including primary motor and sensory cortices, inferior frontal gyrus, and anterior intraparietal area. Nine 16-channel extraneural peripheral nerve electrodes were implanted to allow targeted stimulation of right median, ulnar (2), radial, axillary, musculocutaneous, suprascapular, lateral pectoral, and long thoracic nerves, to produce selective muscle contractions on demand. Proof-of-concept studies were performed to demonstrate feasibility of a bidirectional brain-machine interface to restore function of the participant's own arm and hand. Results: Multi-unit neural activity that correlated with intended motor action was successfully recorded from intracortical arrays. Microstimulation of electrodes in somatosensory cortex produced repeatable sensory percepts of individual fingers for restoration of touch sensation. Selective electrical activation of peripheral nerves produced antigravity muscle contractions. The system was well tolerated with no operative complications. Conclusion: The combination of implanted cortical electrodes and nerve cuff electrodes has the potential to allow restoration of motor and sensory functions of the arm and hand after neurological injury.

Indexed as

Brain-Computer InterfaceBrain-Machine InterfaceFunctional Electrical StimulationMotorNeuromuscular StimulationNeuroprosthesisRestorative NeurosurgerySomatosensationTetraplegia

Identifiers

PMID37162904
PMCPMC10168522
OpenAlexW4367058952

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.