Evidence map›Paper›PMID 37162866›Full record

ArticlebioRxiv : the preprint server for biology2023

Propulsive cell entry diverts pathogens from immune degradation by remodeling the phagocytic synapse.

Zihan Zhang, Thomas K Gaetjens, Yanqi Yu, D Paul Mallory, Steven M Abel, Yan Yu

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Zihan ZhangDepartment of Chemistry, Indiana University, Bloomington, IN 47405-7102.
Thomas K GaetjensDepartment of Chemical and Biomolecular Engineering, University of Tennessee, Knoxville, TN 37996.
Yanqi YuDepartment of Chemistry, Indiana University, Bloomington, IN 47405-7102.
D Paul MalloryDepartment of Chemistry, Indiana University, Bloomington, IN 47405-7102.
Steven M AbelDepartment of Chemical and Biomolecular Engineering, University of Tennessee, Knoxville, TN 37996.
Yan YuDepartment of Chemistry, Indiana University, Bloomington, IN 47405-7102.
Indiana University Bloomington · USUniversity of Tennessee at Knoxville · US

Funding

Unravelling Mechanisms of Endosomal Signaling with Designer NanomaterialsR35GM124918 · NIGMS · WASHINGTON UNIVERSITY · PI Yan Yu · 2017 to 2026
$3.8M
NIGMS NIH HHS R35 GM124918
6 · The paper itself

Abstract

Phagocytosis is a critical immune function for infection control and tissue homeostasis. This process is typically described as non-moving pathogens being internalized and degraded in phagolysosomes. For pathogens that evade immune degradation, the prevailing view is that virulence factors that biochemically disrupt the biogenesis of phagoslysosomes are required. In contrast, here we report that physical forces exerted by pathogens during cell entry divert them away from the canonical phagolysosomal degradation pathway, and this altered intracellular fate is determined at the time of phagocytic synapse formation. We used the eukaryotic parasite

Identifiers

PMID37162866
PMCPMC10168248
OpenAlexW4367301667

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.