Evidence map›Paper›PMID 37162860›Full record

ArticlebioRxiv : the preprint server for biology2023

Tumor cell heterogeneity drives spatial organization of the intratumoral immune response in squamous cell skin carcinoma.

Miho Tanaka, Lotus Lum, Kenneth Hu, Cecilia Ledezma-Soto, Bushra Samad, Daphne Superville, Kenneth Ng, Zoe Adams, Kelly Kersten, Lawrence Fong and 3 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Miho TanakaDepartment of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA.
Lotus LumDepartment of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA.
Kenneth HuUCSF CoLabs, University of California San Francisco, San Francisco, CA, USA.
Cecilia Ledezma-SotoDepartment of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA.
Bushra SamadUCSF CoLabs, University of California San Francisco, San Francisco, CA, USA.
Daphne SupervilleDepartment of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA.
Kenneth NgDepartment of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA.
Zoe AdamsDepartment of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA.
Kelly KerstenDepartment of Pathology, University of California San Francisco, San Francisco, CA, USA.
Lawrence FongDivision of Hematology and Oncology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
Alexis J CombesUCSF CoLabs, University of California San Francisco, San Francisco, CA, USA.
Matthew KrummelDepartment of Pathology, University of California San Francisco, San Francisco, CA, USA.
Melissa ReevesHuntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
University of California, San Francisco · USUniversity of Utah · US

Funding

Evolutionary Trajectories of Tumors Following Resistance to Immune Checkpoint BlockadeR21CA264599 · NCI · UNIVERSITY OF UTAH · PI REEVES, MELISSA QUINO · 2021 to 2022
$411k
NCI NIH HHS R21 CA264599
6 · The paper itself

Abstract

Intratumoral heterogeneity (ITH)-defined as genetic and cellular diversity within a tumor-is linked to failure of immunotherapy and an inferior anti-tumor immune response. The underlying mechanism of this association is unknown. To address this question, we modeled heterogeneous tumors comprised of a pro-inflammatory ("hot") and an immunosuppressive ("cold") tumor population, labeled with YFP and RFP tags respectively to enable precise spatial tracking. The resulting mixed-population tumors exhibited distinct regions comprised of YFP

Indexed as

immune checkpoint blockadeIntratumoral heterogeneityspatial immune heterogeneitytumor immune microenvironment

Identifiers

PMID37162860
PMCPMC10168251
OpenAlexW4367059016

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.