Evidence map›Paper›PMID 37162819›Full record

ArticlebioRxiv : the preprint server for biology2023

Genetic context controls early microglia-synaptic interactions in mouse models of Alzheimer's disease.

Sarah E Heuer, Kelly J Keezer, Amanda A Hewes, Kristen D Onos, Kourtney C Graham, Gareth R Howell, Erik B Bloss

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sarah E HeuerThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
Kelly J KeezerThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
Amanda A HewesThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
Kristen D OnosThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
Kourtney C GrahamThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
Gareth R HowellThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
Erik B BlossThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
Jackson Laboratory · USTufts University · US

Funding

Deconstruction of a Hypothalamic Exercise-responsive Circuit for NeuroprotectionR01AG079877 · NIA · JACKSON LABORATORY · PI Erik Bradley Bloss · 2023 to 2026
$3.1M
Training Program in Precision Genetics of Aging, Alzheimer's Disease and Related DementiasT32AG062409 · NIA · JACKSON LABORATORY · PI Gareth R Howell, KRISTEN M O'CONNELL · 2020 to 2026
$1.5M
NIA NIH HHS R01 AG079877NIA NIH HHS T32 AG062409
6 · The paper itself

Abstract

Common features of Alzheimer's disease (AD) include amyloid pathology, microglia activation and synaptic dysfunction, however, the causal relationships amongst them remains unclear. Further, human data suggest susceptibility and resilience to AD neuropathology is controlled by genetic context, a factor underexplored in mouse models. To this end, we leveraged viral strategies to label an AD-vulnerable neuronal circuit in CA1 dendrites projecting to the frontal cortex in genetically diverse C57BL/6J (B6) and PWK/PhJ (PWK)

Identifiers

PMID37162819
PMCPMC10168315
OpenAlexW4367395105

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.