Evidence map›Paper›PMID 37162799›Full record

ArticleNature and science of sleep2023

The Accuracy and Reliability of Sleep Staging and Sleep Biomarkers in Patients with Isolated Rapid Eye Movement Sleep Behavior Disorder.

Daniel J Levendowski, Thomas C Neylan, Joyce K Lee-Iannotti, Paul C Timm, Cyrus Guevarra, Elise Angel, David Shprecher, Gandis Mazeika, Christine M Walsh, Bradley F Boeve and 1 more

Open access · goldAbstract read
In one paragraph

Article in Nature and science of sleep, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Clinical validation of a wireless patch-based polysomnography system.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Trial
  3. Article
  4. Article
  5. Article
  6. Validation of automated detection of REM sleep without atonia using in-laboratory and in-home recordings.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Article
  7. Review
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Daniel J LevendowskiSleep and Respiratory Research, Advanced Brain Monitoring, Inc, Carlsbad, CA, USA.
Thomas C NeylanWeill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Joyce K Lee-IannottiDepartment of Neurology and Medicine, Banner University Medical Center, Phoenix, AZ, USA.
Paul C TimmMayo Center for Sleep Medicine, Departments of Neurology and Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
Cyrus GuevarraDepartment of Neurology and Medicine, Banner University Medical Center, Phoenix, AZ, USA.
Elise AngelSleep and Respiratory Research, Advanced Brain Monitoring, Inc, Carlsbad, CA, USA.
David ShprecherBanner Sun Health Research Institute, Sun City, AZ, USA.
Gandis MazeikaSleep and Respiratory Research, Advanced Brain Monitoring, Inc, Carlsbad, CA, USA.
Christine M WalshMemory and Aging Center, University of California, San Francisco, CA, USA.
Bradley F BoeveMayo Center for Sleep Medicine, Departments of Neurology and Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
Erik K St LouisMayo Center for Sleep Medicine, Departments of Neurology and Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.ORCID 0000-0002-2833-8826
Advanced Brain Monitoring (United States) · USMayo Clinic · USBanner - University Medical Center Phoenix · USUniversity of California, San Francisco · USBanner Sun Health Research Institute · US

Funding

Multi-site longitudinal Integrated Neurocognitive and Sleep-Behavior Profiler for the Endophenotypic Classification of Dementia Subtypes (INSPECDS)R44AG050326 · NIA · ADVANCED BRAIN MONITORING, INC. · PI BERKA, CHRIS · 2016 to 2024
$4.4M
NIA NIH HHS R44 AG050326
6 · The paper itself

Abstract

Purpose: This study aimed to establish the diagnostic accuracy of a previously validated sleep staging system in patients with probable isolated REM sleep behavior disorder (iRBD), and to compare physicians' diagnoses of iRBD based on REM sleep without atonia (RSWA) to non-REM hypertonia (NRH), a sleep measure independently associated with Parkinsonian spectrum disorders. Patients and Methods: Twenty-six patients with a history of dream enactment behavior underwent a diagnostic PSG with simultaneous Sleep Profiler (SP) acquisition at two sites. PSG and SP records were sleep staged, and two sleep neurologists independently diagnosed iRBD based on the presence or absence of polysomnographic identified RSWA. Comparisons for PSG vs SP sleep staging and the qualitative presence or absence of PSG-based RSWA vs automated SP-detected NRH was performed using kappa coefficients ( Results: The kappa scores from Sites-1 and -2 for PSG vs SP staging were different for Wake ( Conclusion: The potential utility of RSWA and stage N3 as neurodegenerative disorder biomarkers was influenced by between-site variability in visual scoring. The degree to which NRH was associated with iRBD was similar to the between-physician agreement in their diagnosis of iRBD using RSWA.

Indexed as

accuracynon-REM hypertoniaRBDsleep biomarkersleep staging

Identifiers

PMID37162799
PMCPMC10164388
OpenAlexW4367692347

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.