Evidence map›Paper›PMID 37162742›Full record

ReviewCurrent oncology reports2023

Important Considerations in the Diagnosis and Management of Post-transplant Lymphoproliferative Disorder.

Michelle Lee, Aseala Abousaud, R Andrew Harkins, Ellen Marin, Deepali Balasubramani, Michael C Churnetski, Deniz Peker, Ankur Singh, Jean L Koff

Open access · greenAbstract readReview
In one paragraph

Review in Current oncology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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  7. Utility ofAnnals of nuclear medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Michelle LeeMorehouse School of Medicine, Atlanta, GA, USA.
Aseala AbousaudDepartment of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA.
R Andrew HarkinsEmory University School of Medicine, Atlanta, GA, USA.
Ellen MarinDepartment of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Deepali BalasubramaniGeorgia Institute of Technology, Atlanta, GA, USA.
Michael C ChurnetskiDepartment of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Deniz PekerDepartment of Pathology, Emory University, Atlanta, GA, USA.
Ankur SinghGeorgia Institute of Technology, Atlanta, GA, USA.
Jean L KoffDepartment of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA. jkoff@emory.edu.ORCID 0000-0003-4414-0489
Emory University · USGeorgia Institute of Technology · USMorehouse School of Medicine · US

Funding

Hydrogel-based Organoids of African-American Lymphomas to Study B Cell Receptor Pathway InhibitorsR01CA266052 · NCI · GEORGIA INSTITUTE OF TECHNOLOGY · PI JEAN L KOFF, Ankur Singh · 2022 to 2026
$2.7M
NCI NIH HHS R01 CA266052
6 · The paper itself

Abstract

purpose of reviewA relative lack of molecular and clinical studies compared to other lymphoid cancers has historically made it difficult to determine optimal management approaches in post-transplant lymphoproliferative disorder (PTLD). We sought to better define the "state of the science" in PTLD by examining recent advances in risk assessment, genomic profiling, and trials of PTLD-directed therapy. RECENT

findingsSeveral major clinical trials highlight risk-stratified sequential therapy incorporating rituximab with or without chemotherapy as a rational treatment strategy in patients with CD20+ PTLD who do not respond to reduction of immunosuppression alone. Epstein Barr virus (EBV)-targeted cytotoxic lymphocytes are a promising approach in patients with relapsed/refractory EBV+ PTLD, but dedicated clinical trials should determine how autologous chimeric antigen receptor T cell therapy (CAR-T) may be safely administered to PTLD patients. Sequencing studies underscore the important effect of EBV infection on PTLD pathogenesis, but comprehensive genomic and tumor microenvironment profiling are needed to identify biomarkers that predict response to treatment in this clinically heterogeneous disease.

Indexed as

Epstein-Barr Virus InfectionsHematopoietic Stem Cell TransplantationLymphoproliferative DisordersHerpesvirus 4, HumanHumansRituximabRituximabEpstein-Barr virusHematopoietic stem cell transplantPost-transplant lymphoproliferative disorderSolid organ transplant

Identifiers

PMID37162742
PMCPMC10390257
OpenAlexW4376121303

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.