ArticleMolecular biotechnology2024
Sf9 Cell Metabolism Throughout the Recombinant Baculovirus and Rabies Virus-Like Particles Production in Two Culture Systems.
Article in Molecular biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Footprint metabolomic profile shift of Sf9 insect cell line throughout growth and rabies VLP production.Bioprocess and biosystems engineering · 2026Article
- Rheology as a monitoring tool for the biochemical parameters of insect cell-baculovirus system.Biotechnology letters · 2026Article
- Article
- Selecting Raman spectra filtering based on an exhaustive statistical approach for inline bioprocesses monitoring using Sf9 insect cells.Bioprocess and biosystems engineering · 2026Article
- Zika virus-like particle production in a stirred tank bioreactor using a baculovirus/insect cell system.Bioprocess and biosystems engineering · 2025Article
- Multiplicity of infection and culture medium on the SARS-CoV-2 virus like-particles production by baculovirus/insect system.Biotechnology letters · 2025Article
- Establishment & characterization of a non-adherent insect cell line for cultivated meat.Scientific reports · 2025Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
This work aimed to assess the Sf9 cell metabolism during growth, and infection steps with recombinant baculovirus bearing rabies virus proteins, to finally obtain rabies VLP in two culture systems: Schott flask (SF) and stirred tank reactor (STR). Eight assays were performed in SF and STR (four assays in each system) using serum-free SF900 III culture medium. Two non-infection growth kinetics assays and six recombinant baculovirus infection assays. The infection runs were carried out at 0.1 pfu/cell multiplicity of infection (MOI) for single baculovirus bearing rabies glycoprotein (BVG) and matrix protein (BVM) and a coinfection with both baculoviruses at MOI of 3 and 2 pfu/cell for BVG and BVM, respectively. The SF assays were done in triplicate. The glucose, glutamine, glutamate, lactate, and ammonium uptake or release specific rates were quantified over the exponential growth phase and infection stage. The highest uptake specific rate was observed for glucose (42.5 × 10
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