Evidence map›Paper›PMID 37162700›Full record

Trial reportGeroScience2023

Combining exercise with cognitive training and vitamin D

Nick W Bray, Frederico Pieruccini-Faria, Suzanne T Witt, Robert Bartha, Timothy J Doherty, Lindsay S Nagamatsu, Quincy J Almeida, Teresa Liu-Ambrose, Laura E Middleton, Louis Bherer and 1 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in GeroScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02808676 (SYNchronizing Exercises, Remedies in GaIt and Cognition), which is not on this map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02808676 naterminatednot on this map

SYNchronizing Exercises, Remedies in GaIt and Cognition (SYNERGIC): A Randomized Controlled Double Blind Trial

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2016 to 2020Enrolled175ConditionsMild Cognitive ImpairmentArmsVitamin D3, Exercises (E), Cognitive Training (CT), placebo D3, control cognitive training
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
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  6. Clinical Effectiveness of Treatments for Mild Cognitive Impairment in Adults: A Systematic Review.European journal of investigation in health, psychology and education · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Nick W BrayCumming School of Medicine, Department of Physiology & Pharmacology, University of Calgary, Calgary, AB, T2N 1N4, Canada. nicholas.bray@ucalgary.ca.ORCID 0000-0001-5831-7842
Frederico Pieruccini-FariaGait and Brain Lab, Parkwood Institute, Lawson Health Research Institute, 550 Wellington Road, Room A3-116, London, ON, N6C-0A7, Canada.
Suzanne T WittBrainsCAN, Western University, London, ON, N6A-3K7, Canada.
Robert BarthaDepartment of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON, N6A-5C1, Canada.
Timothy J DohertyDepartment of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, ON, N6A-5C1, Canada.
Lindsay S NagamatsuFaculty of Health Sciences, School of Kinesiology, Western University, London, ON, N6G-2V4, Canada.
Quincy J AlmeidaFaculty of Science, Department of Kinesiology and Physical Education, Wilfrid Laurier University, Waterloo, ON, N2L-3C5, Canada.
Teresa Liu-AmbroseDepartment of Physical Therapy, University of British Columbia, Vancouver, BC, V6T-1Z3, Canada.
Laura E MiddletonDepartment of Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON, N2L-3G1, Canada.
Louis BhererDepartment of Medicine, University of Montréal, Montréal, QC, H3T-1J4, Canada.
Manuel Montero-OdassoGait and Brain Lab, Parkwood Institute, Lawson Health Research Institute, 550 Wellington Road, Room A3-116, London, ON, N6C-0A7, Canada. mmontero@uwo.ca.ORCID 0000-0002-5796-2361
Western University · CAMontreal Heart Institute · CAUniversity of Calgary · CAUniversity of Waterloo · CAVancouver Coastal Health · CAWilfrid Laurier University · CA

Funding

CIHR MOP 211220CIHR PJT 153100
6 · The paper itself

Abstract

Changes in functional brain connectivity (FBC) may indicate how lifestyle modifications can prevent the progression to dementia; FBC identifies areas that are spatially separate but temporally synchronized in their activation and is altered in those with mild cognitive impairment (MCI), a prodromal state between healthy cognitive aging and dementia. Participants with MCI were randomly assigned to one of five study arms. Three times per week for 20-weeks, participants performed 30-min of (control) cognitive training, followed by 60-min of (control) physical exercise. Additionally, a vitamin D

Indexed as

Cognitive DysfunctionDementiaAgedAged, 80 and overBrainCholecalciferolCognitive TrainingExerciseHumansCholecalciferolfMRIInterventionMild Cognitive ImpairmentPhysical ExerciseRandomized Controlled Trial

Identifiers

PMID37162700
PMCPMC10170058
OpenAlexW4376122044

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.