Evidence map›Paper›PMID 37162663›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2023

Metabolic syndrome and cognitive deficits in the Greek cohort of Epirus Health Study.

Myrto Koutsonida, Fotios Koskeridis, Georgios Markozannes, Afroditi Kanellopoulou, Abdou Mousas, Evangelos Ntotsikas, Panagiotis Ioannidis, Eleni Aretouli, Konstantinos K Tsilidis

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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Myrto KoutsonidaDepartment of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece.
Fotios KoskeridisDepartment of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece.
Georgios MarkozannesDepartment of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece.
Afroditi KanellopoulouDepartment of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece.
Abdou MousasDepartment of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece.
Evangelos NtotsikasDepartment of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece.
Panagiotis IoannidisB' Department of Neurology, AHEPA University Hospital of Thessaloniki, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Eleni AretouliDepartment of Psychology, School of Social Sciences, University of Ioannina, Ioannina, Greece. earetouli@uoi.gr.
Konstantinos K TsilidisDepartment of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece. k.tsilidis@imperial.ac.uk.ORCID http://orcid.org/0000-0002-8452-8472
University of Ioannina · GRAristotle University of Thessaloniki · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMetabolic syndrome is considered an important risk factor for cognitive decline and dementia. However, the evidence in middle-aged individuals is still conflicting. The aim of the study was to explore the association between metabolic syndrome and its individual components with cognitive function and to investigate possible interaction between sex, age and genetic predisposition for metabolic syndrome and Alzheimer's disease in a middle-aged Greek cohort.

methodsA total of 2,077 healthy adults (mean age: 46.7 years) were included in the primary cross-sectional analysis and 305 of them in secondary prospective analyses. Metabolic syndrome was defined by the revised National Cholesterol Education-Adult Treatment Panel III and the International Diabetes Federation criteria. Cognitive function was measured primarily with the Trail Making, Verbal fluency and Logical Memory test, and in secondary prospective analyses with online versions of Posner cueing task, an emotional recognition task, Corsi block-tapping task and Stroop task.

resultsMultivariable linear regressions showed an association of metabolic syndrome with lower performance in attention (β=1.62 seconds, 95% CI=0.20, 3.04) and memory (β=-0.62 words, 95% CI=-1.19, -0.05) that could be driven by associations with elevated fasting glucose and abdominal obesity. Similar associations were observed in the secondary prospective analyses.

conclusionIn summary, metabolic syndrome was associated with cognitive deficits in domains related with the cognitive profile of vascular cognitive impairment.

Indexed as

Cognitive DysfunctionMetabolic SyndromeAdultCognitionCross-Sectional StudiesGreeceHumansMiddle AgedNeuropsychological TestsProspective Studiesattentioncognitioncomponentsmemorymetabolic syndrome

Identifiers

PMID37162663
PMCPMC10495510
OpenAlexW4376122131

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.