Evidence map›Paper›PMID 37162515›Full record

ArticleEuropean journal of clinical pharmacology2023

Potentially inappropriate medications and cognitive performance: cross-sectional results from the ELSA-Brasil study.

Adriana Nancy Medeiros Dos Santos, Daniela Souza Farias-Itao, Isabela M Benseñor, Alessandra C Goulart, Andre R Brunoni, Maria Carmen Viana, Paulo A Lotufo, Claudia Kimie Suemoto

Erratum issuedAbstract read
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In one paragraph

Article in European journal of clinical pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Adriana Nancy Medeiros Dos SantosDeparment of Internal Medicine, University of Sao Paulo Medical School, São Paulo, Brazil. adriana.nancy.medeiros@usp.br.ORCID http://orcid.org/0000-0002-0705-9895
Daniela Souza Farias-ItaoDepartment of Pathology, University of Sao Paulo Medical School, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-1553-1301
Isabela M BenseñorDeparment of Internal Medicine, University of Sao Paulo Medical School, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-6723-5678
Alessandra C GoulartDeparment of Internal Medicine, University of Sao Paulo Medical School, São Paulo, Brazil.ORCID http://orcid.org/0000-0003-1076-5210
Andre R BrunoniDeparment of Internal Medicine, University of Sao Paulo Medical School, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-6310-3571
Maria Carmen VianaDepartment of Social Medicine, Center of Psychiatric Epidemiology (CEPEP), Postgraduate Program in Public Health, Federal University of Espírito Santo, Vitória, Brazil.ORCID http://orcid.org/0000-0002-0464-4845
Paulo A LotufoDeparment of Internal Medicine, University of Sao Paulo Medical School, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-4856-8450
Claudia Kimie SuemotoCenter for Clinical and Epidemiological Research, University of São Paulo, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0002-5942-4778
Universidade de São Paulo · BRBrazilian Medical Association · BRUniversidade Federal do Espírito Santo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesPotentially inappropriate medications (PIM), especially those with potential effects on the central nervous system, can increase the risk of cognitive impairment. We investigated the association of the use of PIM and PIM that may impair cognition (PIM-Cog) with cognitive performance among older adults.

methodsIn this cross-sectional study with 2,626 participants, PIM and PIM-Cog were defined by the 2019 American Geriatrics Society Beers criteria. We calculated global cognition and memory, verbal fluency, and Trail Making Test B version (TMT-B) z-scores. Linear regression models adjusted for sociodemographic and clinical variables were used to investigate the association between PIM and cognition.

results27% and 7% of the sample (mean age = 65.1 ± 4.1 years old, 54% women, and 61% White) used at least one PIM and PIM-cog, respectively. PIM was associated with poor performance in the TMT-B (β = -0.17, 95% Cl = -0.29; -0.05, p = 0.007). PIM-Cog was also associated with poor TMT-B performance (β = -0.08, 95% Cl = -0.15; -0.01, p = 0.025).

conclusionThe use of PIM and PIM-Cog was associated with poor executive function among older adults. The review of PIM use and the deprescription of these drugs may be an effective way to improve cognitive function.

Indexed as

Cognitive DysfunctionPotentially Inappropriate Medication ListAgedCognitionCross-Sectional StudiesFemaleHumansInappropriate PrescribingMaleMiddle AgedUnited StatesCognitionDementiaDrug utilizationInappropriateMedicationPotentially

Identifiers

PMID37162515
OpenAlexW4376121501

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.