Evidence map›Paper›PMID 37162263›Full record

ArticleBiochemistry2023

The Role of Asn11 in Catalysis by Triosephosphate Isomerase.

Rania Hegazy, Gabriele Cordara, Rik K Wierenga, John P Richard

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Rania HegazyDepartment of Chemistry, University at Buffalo, SUNY, Buffalo, New York 14260-3000, United States.
Gabriele CordaraBiocenter Oulu, University of Oulu, P.O. Box 5000, FIN-90014 Oulu, Finland.ORCID 0000-0001-8029-8043
Rik K WierengaFaculty of Biochemistry and Molecular Medicine, University of Oulu, P.O. Box 5400, FIN-90014 Oulu, Finland.
John P RichardDepartment of Chemistry, University at Buffalo, SUNY, Buffalo, New York 14260-3000, United States.ORCID 0000-0002-0440-2387
University at Buffalo, State University of New York · USUniversity of Oulu · FI

Funding

Studies on Enzyme Activation and Novel Modes of Inhibition. Administrative Supplement for EquipmentR35GM134881 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI John P Richard · 2020 to 2026
$2.5M
NIGMS NIH HHS R35 GM134881
6 · The paper itself

Abstract

Four catalytic amino acids at triosephosphate isomerase (TIM) are highly conserved: N11, K13, H95, and E167. Asparagine 11 is the last of these to be characterized in mutagenesis studies. The ND2 side chain atom of N11 is hydrogen bonded to the O-1 hydroxyl of enzyme-bound dihydroxyacetone phosphate (DHAP), and it sits in an extended chain of hydrogen-bonded side chains that includes T75' from the second subunit. The N11A variants of wild-type TIM from

Indexed as

Amino AcidsTriose-Phosphate IsomeraseCatalysisHydrogenAmino AcidsHydrogenTriose-Phosphate Isomerase

Identifiers

PMID37162263
PMCPMC10249627
OpenAlexW4376109194

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.