Evidence map›Paper›PMID 37161537›Full record

ArticleMalaria journal2023

Use of rapid diagnostic tests for the detection of ancient malaria infections in dental pulp from the sixth century in Versailles, France.

Mahmoud A Boualam, Annick Heitzmann, Florence Mousset, Gérard Aboudharam, Michel Drancourt, Bruno Pradines

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Malaria journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Mahmoud A BoualamIHU Méditerranée Infection, 19-21 Bd Jean Moulin, 13005, Marseille, France.
Annick HeitzmannDirection du Patrimoine et des Jardins, Château de Versailles, Place d'Armes, 78008, Versailles, France.
Florence MoussetDirection régionale des affaires culturelles d'Île-de-France, Service Régional de l'archéologie, 311 Rue Le Peletier, 75009, Paris, France.
Gérard AboudharamIHU Méditerranée Infection, 19-21 Bd Jean Moulin, 13005, Marseille, France.
Michel DrancourtIHU Méditerranée Infection, 19-21 Bd Jean Moulin, 13005, Marseille, France.
Bruno PradinesIHU Méditerranée Infection, 19-21 Bd Jean Moulin, 13005, Marseille, France. bruno.pradines@gmail.com.
Méditerranée Infection Foundation · FRCentre Hospitalier de Versailles · FRInstitut de Médecine Tropicale du Service de Santé des Armées · FRMinistère de la Culture · DZ

Funding

Délégation Générale pour l'Armement NBC-2-B-2120
6 · The paper itself

Abstract

backgroundPaleomicrobiological data have clarified that Plasmodium spp. was circulating in the past in southern European populations, which are now devoid of malaria. The aim of this study was to evaluate the efficacy of immunodetection and, more particularly, rapid diagnostic tests (RDT), in order to further assess Plasmodium infections in ancient northern European populations.

methodsA commercially available RDT, PALUTOP

resultsPlasmodium antigens were detected in 14/39 (35.9%) individuals, including Plasmodium vivax antigens in 11 individuals and Plasmodium falciparum antigens co-detected in two individuals, while Pan-Plasmodium antigens were detected in three individuals. Controls all yielded expected results.

conclusionsThe data reported here showed that RDTs are a suitable tool for detecting Plasmodium spp. antigens in ancient dental pulp samples, and demonstrated the existence of malaria in Versailles, France, in the sixth century. Plasmodium vivax, which is regarded as being responsible for an attenuated form of malaria and less deadly forms, was the most prevalent species. This illustrates, for the first time in ancient populations, co-infection with P. falciparum, bringing into question the climate-driven ecosystems prevailing at that time in the Versailles area.

Indexed as

MalariaMalaria, FalciparumAntigens, ProtozoanDental PulpEcosystemFranceHumansRapid Diagnostic TestsAntigens, ProtozoanAncient malariaCo-infectionEuropeImmunodetectionPaleomicrobiologyPlasmodium falciparumPlasmodium vivax

Identifiers

PMID37161537
PMCPMC10169320
OpenAlexW4376115798

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.