Evidence map›Paper›PMID 37161382›Full record

ArticleBMC pregnancy and childbirth2023

Adverse infant outcomes following low-risk pregnancies in England: a retrospective cohort study.

Megan Riley, Dimitra Lambrelli, Sophie Graham, Ouzama Henry, Andrea Sutherland, Alexander Schmidt, Nicola Sawalhi-Leckenby, Robert Donaldson, Sonia K Stoszek

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pregnancy and childbirth, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Megan RileyGSK, 14200 Shady Grove Rd, Rockville, MD 20850, USA. megan.x.riley@gsk.com.
Dimitra LambrelliEvidera, 201 Talgarth Rd, Hammersmith, W6 8BJ, London, UK.
Sophie GrahamEvidera, 201 Talgarth Rd, Hammersmith, W6 8BJ, London, UK.
Ouzama HenryGSK, 14200 Shady Grove Rd, Rockville, MD 20850, USA.
Andrea SutherlandGSK, 14200 Shady Grove Rd, Rockville, MD 20850, USA.
Alexander SchmidtGSK, 14200 Shady Grove Rd, Rockville, MD 20850, USA.
Nicola Sawalhi-LeckenbyEvidera, 201 Talgarth Rd, Hammersmith, W6 8BJ, London, UK.
Robert DonaldsonEvidera, 201 Talgarth Rd, Hammersmith, W6 8BJ, London, UK.
Sonia K StoszekGSK, 14200 Shady Grove Rd, Rockville, MD 20850, USA.
Hammersmith Hospital · GBGlaxoSmithKline (United States) · USBill & Melinda Gates Foundation · USUniversities at Shady Grove · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere are limited data describing adverse infant outcomes in infants born to women with a low risk of complications during pregnancy, such as those who may be enrolled in maternal immunization trials. This retrospective study estimated incidence proportions of infant outcomes in different cohorts of liveborn infants in England between 2005 and 2017.

methodsThe incidence proportions of 10 infant outcomes were calculated for liveborn infants from pregnancies represented in the Clinical Practice Research Datalink (CPRD) Mother-Baby Link (MBL) and linkage to Hospital Episode Statistics (HES). Three infant cohorts were designed: (1) the all pregnancies infants cohort (N = 185,119), (2) the all pregnancies with a gestational age (GA) ≥ 24 weeks infants cohort (N = 183,869), and (3) the low-risk pregnancies infants cohort (LR infants cohort, N = 121,871), which included pregnancies with a GA ≥ 24 weeks and no diagnosis of predefined high-risk medical conditions until 24 weeks GA.

resultsThe most common adverse infant outcome in the three infant cohorts was macrosomia (e.g., 1,085.9/10,000 live births in the LR infants cohort), followed by minor congenital anomalies (e.g., 800.6/10,000 in the LR infants cohort), very low/low birth weight (e.g., 400.6/10,000 in the LR infants cohort), and major congenital anomalies (e.g., 270.4/10,000 in the LR infants cohort). The incidence proportions for early-onset sepsis, very low/low birth weight, and minor and major congenital anomalies were lower in the LR infants than in the other cohorts (non-overlapping confidence intervals [CIs]). The incidence proportions of neonatal death, infant death, late-onset sepsis, macrosomia, small for GA, and large for GA were similar between cohorts (overlapping CIs).

conclusionsThis study generated background rates of adverse infant outcomes from liveborn infants of all and low-risk pregnancies represented in the CPRD Pregnancy Register MBL and linkage to HES. The results indicate lower incidence proportions of several adverse infant outcomes in infants from low-risk pregnancies compared to all pregnancies, illustrating the importance of considering maternal risk factors. These background rates may facilitate the interpretation of safety data from maternal immunization trials and of pharmacovigilance data from maternal vaccines. They may also be of interest for other interventions studied in pregnant women.

Indexed as

Fetal MacrosomiaMothersEnglandFemaleGestational AgeHumansInfantInfant, NewbornPregnancyRetrospective StudiesBackground rateInfant outcomesLow-risk pregnancyMaternal immunization trialMaternal vaccinationPharmacovigilance

Identifiers

PMID37161382
PMCPMC10170847
OpenAlexW4376115751

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.