Evidence map›Paper›PMID 37161349›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2023

Paramagnetic rim lesions are associated with greater incidence of relapse and worse cognitive recovery following relapse.

Jack A Reeves, Zachary Weinstock, Robert Zivadinov, Michael G Dwyer, Niels Bergsland, Fahad Salman, Ferdinand Schweser, Bianca Weinstock-Guttman, Ralph Hb Benedict, Dejan Jakimovski

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Jack A ReevesBuffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.
Zachary WeinstockBuffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.ORCID 0000-0002-2929-8432
Robert ZivadinovBuffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA/Center for Biomedical Imaging at the Clinical Translational Science Institute, University at Buffalo, State University of New York, Buffalo, NY, USA.ORCID 0000-0002-7799-1485
Michael G DwyerBuffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA/Center for Biomedical Imaging at the Clinical Translational Science Institute, University at Buffalo, State University of New York, Buffalo, NY, USA.
Niels BergslandBuffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA/IRCCS, Fondazione Don Carlo Gnocchi, Milan, Italy.ORCID 0000-0002-7792-0433
Fahad SalmanBuffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.
Ferdinand SchweserBuffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA/Center for Biomedical Imaging at the Clinical Translational Science Institute, University at Buffalo, State University of New York, Buffalo, NY, USA.
Bianca Weinstock-GuttmanDepartment of Neurology, Jacobs Comprehensive MS Treatment and Research Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.ORCID 0000-0001-6732-151X
Ralph Hb BenedictDepartment of Neurology, Jacobs Comprehensive MS Treatment and Research Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.
Dejan JakimovskiBuffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.ORCID 0000-0001-7114-4958
University at Buffalo, State University of New York · USJacobs Institute · USDon Carlo Gnocchi Foundation · IT

Funding

University of Buffalo Clinical and Translational Science Institute - Supplement SchulyerUL1TR001412 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MURPHY, TIMOTHY F · 2015 to 2024
$33.8M
Deep Gray Matter Iron and Disease Progression in Multiple SclerosisR01NS114227 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI SCHWESER, FERDINAND · 2021 to 2024
$1.5M
NCATS NIH HHS UL1 TR001412NINDS NIH HHS R01 NS114227
6 · The paper itself

Abstract

backgroundParamagnetic rim lesions (PRL) may be linked to relapse risk of people with relapsing-remitting multiple sclerosis (pwRRMS).

objectiveTo determine the relationship between presence of PRL lesions and cognitive recovery after relapse.

methodsPRL load was compared between acutely relapsing pwRRMS and matched stable pwRRMS controls (each group

resultsAcutely relapsing pwRRMS had significantly greater prevalence and number of PRL (

conclusionThese findings may partially explain previously suggested associations between presence of PRL with more severe disease course.

Indexed as

Multiple SclerosisMultiple Sclerosis, Relapsing-RemittingBrainChronic DiseaseCognitionHumansIncidenceMagnetic Resonance ImagingRecurrencecognitive recoverymultiple sclerosisParamagnetic rim lesionquantitative susceptibility mapping (QSM)relapsesusceptibility weighted imaging (SWI)

Identifiers

PMID37161349
PMCPMC10523891
OpenAlexW4376118284

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.