Evidence map›Paper›PMID 37161046›Full record

ArticleScientific reports2023

Endogenous myoglobin expression in mouse models of mammary carcinoma reduces hypoxia and metastasis in PyMT mice.

Mostafa A Aboouf, Julia Armbruster, Franco Guscetti, Markus Thiersch, Andreas Boss, Axel Gödecke, Sandra Winning, Claudia Padberg, Joachim Fandrey, Glen Kristiansen and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 3 countries.

Mostafa A Aboouf *Institute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057, Zurich, Switzerland.
Julia Armbruster *Institute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057, Zurich, Switzerland.
Franco GuscettiInstitute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, 8057, Zurich, Switzerland.
Markus ThierschInstitute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057, Zurich, Switzerland.
Andreas BossDepartment of Diagnostic and Interventional Radiology, University Hospital Zurich, 8091, Zurich, Switzerland.
Axel GödeckeInstitute of Cardiovascular Pathology, Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany.
Sandra WinningInstitute for Physiology, University Duisburg-Essen, 47057, Essen, Germany.
Claudia PadbergInstitute for Physiology, University Duisburg-Essen, 47057, Essen, Germany.
Joachim FandreyInstitute for Physiology, University Duisburg-Essen, 47057, Essen, Germany.
Glen KristiansenInstitute of Pathology, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.
Anne BickerInstitute of Organismic and Molecular Evolution, Molecular and Genome Analysis, Johannes Gutenberg University, 55099, Mainz, Germany.
Thomas HankelnInstitute of Organismic and Molecular Evolution, Molecular and Genome Analysis, Johannes Gutenberg University, 55099, Mainz, Germany.
Max GassmannInstitute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057, Zurich, Switzerland.
Thomas A GorrInstitute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057, Zurich, Switzerland. tgorr@access.uzh.ch.
University of Zurich · CHUniversity of Duisburg-Essen · DEHeinrich Heine University Düsseldorf · DEJohannes Gutenberg University Mainz · DEUniversity Hospital Bonn · DEUniversity Hospital of Zurich · CHUniversity Medical Center of the Johannes Gutenberg University Mainz · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myoglobin (MB) is expressed in different cancer types and may act as a tumor suppressor in breast cancer. The mechanisms by which basal MB expression level impacts murine mammary tumorigenesis are unclear. We investigated how MB expression in breast cancer influences proliferation, metastasis, tumor hypoxia, and chemotherapy treatment in vivo. We crossed PyMT and WapCreTrp53

Indexed as

CarcinomaMyoglobinAnimalsBiopsyDisease Models, AnimalHypoxiaMiceMice, KnockoutMyoglobin

Identifiers

PMID37161046
PMCPMC10170105
OpenAlexW4376131313

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.