Evidence map›Paper›PMID 37161045›Full record

ArticleScientific reports2023

Functional and phosphoproteomic analysis of β-adrenergic receptor signaling at excitatory synapses in the CA1 region of the ventral hippocampus.

Shekib A Jami, Brent J Wilkinson, Ryan Guglietta, Nicolas Hartel, Walter E Babiec, Nicholas A Graham, Marcelo P Coba, Thomas J O'Dell

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Shekib A JamiMolecular, Cellular, and Integrative Physiology Interdepartmental PhD Program, University of California, Los Angeles, Los Angeles, CA, USA.
Brent J WilkinsonZilkha Neurogenetic Institute, Los Angeles, CA, USA.
Ryan GugliettaInterdepartmental PhD Program for Neuroscience, University of California, Los Angeles, Los Angeles, CA, USA.
Nicolas HartelMork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, CA, USA.
Walter E BabiecUndergraduate Interdepartmental Program for Neuroscience, University of California, Los Angeles, Los Angeles, CA, USA.
Nicholas A GrahamMork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, CA, USA.
Marcelo P CobaZilkha Neurogenetic Institute, Los Angeles, CA, USA.
Thomas J O'DellIntegrative Center for Learning and Memory, Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA. todell@mednet.ucla.edu.
University of California, Los Angeles · USUniversity of Southern California · US

Funding

Regulation of postsynaptic protein interaction networks in complex brain disordersR01MH115005 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI COBA, MARCELO PABLO · 2018 to 2022
$2.9M
Regulation of PSD phosphorylation and protein interactions networks by LTPR21MH113949 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI COBA, MARCELO PABLO · 2017 to 2018
$437k
NIMH NIH HHS 1R21 MH113949NIMH NIH HHS R01 MH115005
6 · The paper itself

Abstract

Activation of β-adrenergic receptors (β-ARs) not only enhances learning and memory but also facilitates the induction of long-term potentiation (LTP), a form of synaptic plasticity involved in memory formation. To identify the mechanisms underlying β-AR-dependent forms of LTP we examined the effects of the β-AR agonist isoproterenol on LTP induction at excitatory synapses onto CA1 pyramidal cells in the ventral hippocampus. LTP induction at these synapses is inhibited by activation of SK-type K

Indexed as

Receptors, Adrenergic, betaSignal TransductionHippocampusIsoproterenolLong-Term PotentiationIsoproterenolReceptors, Adrenergic, beta

Identifiers

PMID37161045
PMCPMC10170123
OpenAlexW4376131928

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.