Evidence map›Paper›PMID 37160898›Full record

ArticleNature communications2023

Resveratrol intervention attenuates chylomicron secretion via repressing intestinal FXR-induced expression of scavenger receptor SR-B1.

Juan Pang, Fitore Raka, Alya Abbas Heirali, Weijuan Shao, Dinghui Liu, Jianqiu Gu, Jia Nuo Feng, Chieko Mineo, Philip W Shaul, Xiaoxian Qian and 4 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 47 citations in OpenAlex.

  1. Trial
  2. Compound Abrus cantoniensis Extract Alleviates AFBAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
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  11. Magnetite Micro/Nanorobots for Efficient Targeted Alleviation of Inflammatory Bowel Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Juan Pang *Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, PR China.ORCID 0000-0001-6272-9890
Fitore Raka *Department of Molecular Structure and Function Research Institute, The Hospital for Sick Children, Toronto, ON, Canada.
Alya Abbas HeiraliDepartment of Medicine, Division of Infectious Diseases, University Health Network, Toronto, ON, Canada.
Weijuan ShaoDivision of Advanced Diagnostics, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Dinghui LiuDepartment of Cardiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China.
Jianqiu GuDepartment of Endocrinology and Metabolism and The Institute of Endocrinology, The First Hospital of China Medical University, Shenyang, PR China.
Jia Nuo FengDivision of Advanced Diagnostics, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Chieko MineoDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Philip W ShaulDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0003-1157-4002
Xiaoxian QianDepartment of Cardiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China.
Bryan CoburnDepartment of Medicine, Division of Infectious Diseases, University Health Network, Toronto, ON, Canada.ORCID 0000-0003-0150-4510
Khosrow AdeliDepartment of Molecular Structure and Function Research Institute, The Hospital for Sick Children, Toronto, ON, Canada. k.adeli@utoronto.ca.ORCID 0000-0002-5839-5709
Wenhua LingDepartment of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, PR China. lingwh@mail.sysu.edu.cn.ORCID 0000-0002-5468-6605
Tianru JinDivision of Advanced Diagnostics, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada. tianru.jin@utoronto.ca.ORCID 0000-0002-0307-7391
University Health Network · CASun Yat-sen University · CNThe University of Texas Southwestern Medical Center · USUniversity of Toronto · CAFirst Hospital of China Medical University · CN

Funding

Dichotomous Role of Endothelial SR-BI in AtherosclerosisR01HL131597 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI SHAUL, PHILIP W · 2017 to 2020
$1.6M
CIHR PJT159735NHLBI NIH HHS R01 HL131597
6 · The paper itself

Abstract

Two common features of dietary polyphenols have hampered our mechanistic understanding of their beneficial effects for decades: targeting multiple organs and extremely low bioavailability. We show here that resveratrol intervention (REV-I) in high-fat diet (HFD)-challenged male mice inhibits chylomicron secretion, associated with reduced expression of jejunal but not hepatic scavenger receptor class B type 1 (SR-B1). Intestinal mucosa-specific SR-B1

Indexed as

ChylomicronsPolyphenolsAnimalsCaco-2 CellsHumansMaleMiceReceptors, ScavengerResveratrolChylomicronsPolyphenolsReceptors, ScavengerResveratrol

Identifiers

PMID37160898
PMCPMC10169763
OpenAlexW4376131749

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.