Evidence map›Paper›PMID 37160795›Full record

ArticleBulletin of experimental biology and medicine2023

Morphofunctional Changes in the Spinal Cord of Rats after Contusion Injury with Local Delivery of Methylprednisolone in Combination with a Copolymer.

M E Baltin, D E Sabirova, O N Chernova, T V Baltina, O A Sachenkov

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

M E BaltinInstitute of Fundamental Medicine and Biology, Kazan (Volga region) Federal University, Kazan, Republic of Tatarstan, Russia.
D E SabirovaInstitute of Fundamental Medicine and Biology, Kazan (Volga region) Federal University, Kazan, Republic of Tatarstan, Russia.
O N ChernovaMedical Social Institute, St Petersburg, Russia.
T V BaltinaInstitute of Fundamental Medicine and Biology, Kazan (Volga region) Federal University, Kazan, Republic of Tatarstan, Russia. tvbaltina@gmail.com.
O A SachenkovN. I. Lobachevsky Institute of Mathematics and Mechanics, Kazan (Volga region) Federal University, Kazan, Republic of Tatarstan, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied the neuroprotective effect of local application of methylprednisolone in combination with a block copolymer after contusion spinal cord injury in rats. Histological analysis of the spinal cord showed that delivery of a complex of methylprednisolone with a block copolymer reduced the volume of white and gray matter lesions. An increase in the amplitude of the evoked response of the gastrocnemius muscle was observed during epidural stimulation of the spinal cord 6 h after the injury. The maximum amplitude of the muscle response was greater in the group with local delivery of the methylprednisolone complex with the polymer 72 h after the injury. The obtained results demonstrate the neuroprotective effect of the local administration of the complex and allow to make positive prognosis for the recovery of the sensorimotor functions in rats.

Indexed as

ContusionsNeuroprotective AgentsSpinal Cord InjuriesAnimalsMethylprednisoloneRatsSpinal CordMethylprednisoloneNeuroprotective Agentsevoked muscle responsesmethylprednisolonemorphometric analysisspinal cord injurytrifunctional block copolymer

Identifiers

PMID37160795

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.