ArticleLung2023
Characteristics and Management of Patients with Refractory or Unexplained Chronic Cough in Outpatient Hospital Clinics in Spain: A Retrospective Multicenter Study.
Article in Lung, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 17 citations in OpenAlex.
- Camlipixant in Refractory Chronic Cough: A Phase 2b, Randomized, Placebo-controlled Trial (SOOTHE).American journal of respiratory and critical care medicine · 2025Trial
- Challenges and Burdens in Refractory Chronic Cough: Patients' and Physicians' Perspectives.Pulmonary therapy · 2026Review
- Clarifying Terminology in Chronic Cough: The Evolving Role of Cough Hypersensitivity Syndrome.The clinical respiratory journal · 2026Review
- Clinical impact and healthcare resource utilisation in patients with unexplained or refractory chronic cough: a French national population study.ERJ open research · 2026Article
- Female predominance in chronic cough: biological sex-related factors, mechanisms, and therapeutic targets-a narrative review.Frontiers in medicine · 2026Review
- How Will a Treatable Traits Approach Reshape Clinical Practice in Chronic Cough?Allergy, asthma & immunology research · 2025Review
- Prevalence of refractory and unexplained chronic cough in adults treated in cough centre.ERJ open research · 2024Article
- LUNG Year in Review: 2023.Lung · 2024Article
- Patient's experiences of coughing after lung cancer surgery: A multicenter qualitative study.Cancer medicine · 2024Article
- Consensus goals and standards for specialist cough clinics: the NEUROCOUGH international Delphi study.ERJ open research · 2023Article
- Burden of refractory and unexplained chronic cough on patients' lives: a cohort study.ERJ open research · 2023Article
- Article
- Diagnosed and undiagnosed cough-related stress urinary incontinence in women with refractory or unexplained chronic cough: Its impact on general health status and quality of life.Chronic respiratory diseaseArticle
- Emotions in patients with refractory or unexplained chronic cough: a multicenter, non-interventional study.Therapeutic advances in respiratory diseaseArticle
- Chronic Cough Among Primary Care Doctors: Unmet Needs.Open respiratory archivesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 9 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeChronic cough (cough that persists for ≥ 8 weeks) can cause a range of physical symptoms and psychosocial effects that significantly impair patients' quality of life. Refractory chronic cough (RCC) and unexplained chronic cough (UCC) are challenging to diagnose and manage, with substantial economic implications for healthcare systems.
methodsThis retrospective multicenter non-interventional study aimed to characterize the profile and health resource consumption of patients with RCC or UCC who attended outpatient clinics at Spanish hospitals. Data were collected from medical records of patients with RCC or UCC for up to 3 years before study inclusion.
resultsThe patient cohort (n = 196) was representative of the chronic cough population (77.6% female, mean age 58.5 years). Two-thirds of patients (n = 126) had RCC. The most frequently visited doctors were pulmonologists (93.4% of patients) and primary care physicians (78.6%), with a mean of 5 visits per patient over three years' observation. The most common diagnostic tests were chest x-ray (83.7%) and spirometry with bronchodilation (77.0%). The most commonly prescribed treatments were proton pump inhibitors (79.6%) and respiratory medications (87.8%). Antibiotics were prescribed empirically to 56 (28.6%) patients. Differences between RCC or UCC groups related mainly to approaches used to manage cough-associated conditions (gastroesophageal reflux disease, asthma) in patients with RCC.
conclusionRCC and UCC are responsible for high health resource utilization in Spanish hospitals. Specific treatments targeting the pathological processes driving chronic cough may provide opportunities to reduce the associated burden for patients and healthcare systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.