Evidence map›Paper›PMID 37160602›Full record

ArticleBulletin of experimental biology and medicine2023

Changes in Secretion of the Thyroid and Pituitary Glands with a Gradual Decrease in Deuterium Body Content.

N V Yaglova, S S Obernikhin, E P Timokhina, V V Yaglov, S V Nazimova

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

N V YaglovaLaboratory of Endocrine System Development, A. P. Avtsyn Research Institute of Human Morphology, , A. P. Petrovsky Russian Research Center of Surgery, Moscow, Russia. yaglova@mail.ru.
S S ObernikhinLaboratory of Endocrine System Development, A. P. Avtsyn Research Institute of Human Morphology, , A. P. Petrovsky Russian Research Center of Surgery, Moscow, Russia.
E P TimokhinaLaboratory of Endocrine System Development, A. P. Avtsyn Research Institute of Human Morphology, , A. P. Petrovsky Russian Research Center of Surgery, Moscow, Russia.
V V YaglovLaboratory of Endocrine System Development, A. P. Avtsyn Research Institute of Human Morphology, , A. P. Petrovsky Russian Research Center of Surgery, Moscow, Russia.
S V NazimovaLaboratory of Endocrine System Development, A. P. Avtsyn Research Institute of Human Morphology, , A. P. Petrovsky Russian Research Center of Surgery, Moscow, Russia.
Research Institute of Human Morphology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied changes in the secretion of thyroid hormones and pituitary thyroid-stimulating hormone (TSH) in young mature male Wistar rats during gradual decrease in deuterium body content. The rats received deuterium-depleted water ([D]=10 ppm) instead of tap water for 21 days. As soon as after 1 day, an increase in the secretion of thyroid hormones was recorded. On day 14, secondary hypothyroidism due to a sharp decrease in TSH secretion by the pituitary gland was found. By day 21, secretion of the thyroid hormones increased, and the reciprocal dependence between the concentrations of thyroid hormones and TSH was restored. Thus, the thyroid gland showed a higher sensitivity to a decrease in the deuterium content in the body than the hypothalamic-pituitary complex. The second difference was in type of response: activation of the secretory processes in the thyroid gland and a transient decrease in the secretory activity of pituitary gland thyrotropes to a decrease in deuterium content.

Indexed as

Pituitary GlandThyroid GlandAnimalsDeuteriumMaleRatsRats, WistarThyroid HormonesThyrotropinThyroxineDeuteriumThyroid HormonesThyrotropinThyroxinedeuteriumpituitarythyroidthyroid hormones

Identifiers

PMID37160602
OpenAlexW4376108579

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.