Evidence map›Paper›PMID 37160588›Full record

ArticleProbiotics and antimicrobial proteins2024

Understanding the Effect of Compound Probiotics on the Health of Rabbits and Its Mechanisms Through Metagenomics.

Xiaohong Hou, Peiqiang Dai, Xingdong Song, Xianrong Long, Jing Gao, Tongjie Chai

Abstract read
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In one paragraph

Article in Probiotics and antimicrobial proteins, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Complete genome analysis ofFrontiers in microbiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Xiaohong HouCollege of Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450000, China.
Peiqiang DaiSino-Science Biological Research Institute, Taian, China.
Xingdong SongCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, China.
Xianrong LongCollege of Animal Science and Veterinary Medicine, Shandong Agricultural University, Taian, 271000, China.
Jing GaoTaian Central Hospital, Taian, 271000, China. gaojingkq@163.com.
Tongjie ChaiCollege of Animal Science and Veterinary Medicine, Shandong Agricultural University, Taian, 271000, China. chaitj117@163.com.
Shandong Agricultural University · CNHenan Agricultural University · CNNortheast Forestry University · CNTaian City Central Hospital · CN

Funding

Key Technology Research and Development Program of Shandong 2016GNC110014
6 · The paper itself

Abstract

In this study, we investigated the effects of probiotics on growth performance, immunity, intestinal flora, and antioxidant capacity of rabbits. Three hundred New Zealand white rabbits were randomly divided into four groups. Groups A, B, C, and D were the lactobacillus group, compound probiotic group, control group, and antibiotic group, respectively. The results showed compared with the control group, the average weight of groups A, B, and D increased by 14.88%, 12.33%, and 11.97%, respectively. Moreover, the index of immune organs and the IgG and IgM in serum of group B were significantly increased (P < 0.05). Meanwhile, the activities of superoxide dismutase (SOD) in group B and catalase (CAT) in group A were significantly increased (P < 0.05). At week 5, the contents of rabbit cecum were taken for metagenome sequencing, and the results showed probiotics increased the relative abundance of Akkermansia, and decreased the relative abundance of Bacteroides. According to the Kyoto Encyclopedia of Genes and Genomes (KEGG) database, we found probiotics could enrich metabolic pathways such as carbohydrates, amino acids, and lipids. According to the Comprehensive Antibiotic Resistance Database (CARD), we found antibiotic resistance ontology (ARO) in cecum mainly included β-lactamases, macrolide 2'-phosphotransferase II, and plasmid-mediated quinolone resistance protein. Among them, there were 1964, 2105, and 1982 types of ARO in group B, group D, and groups A and C, respectively. These results showed probiotics played a beneficial role in maintaining or enhancing the health and growth of rabbits and could replace antibiotics under certain feeding conditions.

Indexed as

Gastrointestinal MicrobiomeMetagenomicsProbioticsAnimalsAnti-Bacterial AgentsBacteriaCecumLactobacillusMaleRabbitsSuperoxide DismutaseAnti-Bacterial AgentsSuperoxide DismutaseAROCompound probioticsMetagenomeMicrobial diversity

Identifiers

PMID37160588
OpenAlexW4376105182

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.