ArticleBMJ open2023
Prevalence of multimorbidity and its associations with hospitalisation or death in Japan 2014-2019: a retrospective cohort study using nationwide medical claims data in the middle-aged generation.
Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Age-period-cohort analysis of multimorbidity prevalence among Chinese older adults: from 2002 to 2022.GeroScience · 2026Article
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- Associations of diverse diseases with work productivity among Japanese workers in the context of multimorbidity: additional analysis of a database study.Journal of occupational health · 2026Article
- Unlocking the value of RSV vaccination in Japan: a return on investment analysis using an integrated actuarial-macroeconomic model.Frontiers in public health · 2026Article
- Sex differences in the burden of multiple long-term conditions among Japanese individuals with heart failure.Open heart · 2025Article
- Healthy lifestyle, multimorbidity and all-cause mortality among older people: a retrospective cohort study based on CLHLS 2005-2018.BMC geriatrics · 2025Article
- Assessing Knowledge, Attitudes, and Practices Towards Herpes Zoster and Vaccination in Japan Using the Capability-Opportunity-Motivation-Behavior Model: a Mixed-Methods Study.International journal of public health · 2025Article
- Chronic Disease Patterns and Their Relationship With Health-Related Quality of Life in South Korean Older Adults With the 2021 Korean National Health and Nutrition Examination Survey: Latent Class Analysis.JMIR public health and surveillance · 2024Article
- The Relationship Between the Number of Chronic Diseases and Health-Related Quality of Life Among Middle-Aged and Older Adults in Rural Areas of Yunnan Province, China: moderating Effect of Health Lifestyle.Journal of multidisciplinary healthcare · 2024Article
- Cardiometabolic multimorbidity in Mexican adults: a cross-sectional analysis of a national survey.Frontiers in medicine · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo describe the prevalence of multimorbidity and its associations with clinical outcomes across age groups.
designRetrospective cohort study using nationwide medical claims data.
settingCarried out in Japan between April 2014 and March 2019.
participantsN=246 671 Japanese individuals aged 20-74 enrolled in the health insurance were included into the baseline data set for fiscal year (FY) 2014. Of those, N=181 959 individuals were included into the cohort data set spanning FY2014-FY2018. EXPOSURES: Multimorbidity was defined as having ≥2 of 15 chronic conditions according to the International Classification of Diseases 10th Revision codes of the Charlson Comorbidity Index. PRIMARY AND SECONDARY OUTCOMES: Primary outcome: the standardised prevalence of multimorbidity across age groups was evaluated using data from FY2014 and extrapolated to the Japanese total population. SECONDARY OUTCOME: hospitalisation or death events were traced by month using medical claims data and insurer enrolment data. Associations between multimorbidity and 5-year hospitalisation and/or death events across age groups were analysed using a Cox regression model.
resultsThe standardised prevalence rate of multimorbidity in the nationwide Japanese total population was estimated to 26.1%. The prevalence rate with age was increased, approximately 5% (ages 20-29), 10% (30-39), 20% (40-49), 30% (50-59), 50% (60-69) and 60% (70-74). Compared with individuals aged 20-39 without multimorbidity, those with multimorbidity had a higher incidence of clinical events in any age group (HR=2.43 (95% CI 2.30 to 2.56) in ages 20-39, HR=2.55 (95% CI 2.47 to 2.63) in ages 40-59 and HR=3.41 (95% CI 3.23 to 3.53) in ages ≥60). The difference in the incidence of clinical events between multimorbidity and no multimorbidity was larger than that between age groups.
conclusionsMultimorbidity is already prevalent in the middle-aged generation and is associated with poor clinical outcomes. These findings underscore the significance of multimorbidity and highlight the urgent need for preventive intervention at the public healthcare level.
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