Evidence map›Paper›PMID 37160367›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023

Seizures Cause Prolonged Impairment of Ventilation, CO

Frida A Teran, Rup K Sainju, Eduardo Bravo, Jacy Wagnon, YuJaung Kim, Alex Granner, Brian K Gehlbach, George B Richerson

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
9.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Frida A TeranDepartment of Neurology, University of Iowa, Iowa City, Iowa 52242 frida-teran@uiowa.edu.
Rup K SainjuDepartment of Neurology, University of Iowa, Iowa City, Iowa 52242.
Eduardo BravoDepartment of Neurology, University of Iowa, Iowa City, Iowa 52242.
Jacy WagnonDepartment of Neuroscience, The Ohio State University, Columbus, Ohio 43210.
YuJaung KimDepartment of Neurology, University of Iowa, Iowa City, Iowa 52242.
Alex GrannerDepartment of Neurology, University of Iowa, Iowa City, Iowa 52242.
Brian K GehlbachDepartment of Internal Medicine, University of Iowa, Iowa City, Iowa 52242.
George B RichersonDepartment of Neurology, University of Iowa, Iowa City, Iowa 52242.ORCID 0000-0001-5696-1554
University of Iowa · USThe Ohio State University · US

Funding

SUDEP Translational Research Alliance (SUTRA): Autonomic and Imaging Biomarkers of SUDEP; SUTRA 3 of 7U01NS090407 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DIEHL, BEATE, HARPER, RONALD MARVEN · 2014 to 2018
$7.3M
The role of central CO2 chemosensitivity in postictal respiratory depression and SUDEPR01NS113764 · NINDS · UNIVERSITY OF IOWA · PI Brian Gehlbach, GEORGE B RICHERSON · 2019 to 2026
$5.5M
SUDEP Research Alliance: Respiratory and Arousal Mechanisms, Application 5 of 7U01NS090414 · NINDS · UNIVERSITY OF IOWA · PI RICHERSON, GEORGE B · 2014 to 2018
$3.3M
Prevention of SUDEP by milk whey: Role of CO2 chemoreception and serotoninR01NS123155 · NINDS · UNIVERSITY OF IOWA · PI RICHERSON, GEORGE B · 2021 to 2025
$2.9M
A novel dietary therapy for epilepsy: potential mechanisms of actionF31NS110333 · NINDS · UNIVERSITY OF IOWA · PI TERAN, FRIDA ANGELINA · 2018 to 2021
$153k
NINDS NIH HHS F31 NS110333NINDS NIH HHS R01 NS113764NINDS NIH HHS R01 NS123155NINDS NIH HHS U01 NS090407NINDS NIH HHS U01 NS090414
6 · The paper itself

Abstract

Sudden unexpected death in epilepsy (SUDEP) has been linked to respiratory dysfunction, but the mechanisms underlying this association remain unclear. Here we found that both focal and generalized convulsive seizures (GCSs) in epilepsy patients caused a prolonged decrease in the hypercapnic ventilatory response (HCVR; a measure of respiratory CO

Indexed as

EpilepsyHypothermiaRespiration DisordersSudden Unexpected Death in EpilepsyAnimalsBody Temperature RegulationCarbon DioxideDeath, SuddenFemaleFenfluramineMaleMiceNAV1.1 Voltage-Gated Sodium ChannelNAV1.6 Voltage-Gated Sodium ChannelRespirationSeizuresCarbon DioxideFenfluramineNAV1.1 Voltage-Gated Sodium ChannelNAV1.6 Voltage-Gated Sodium ChannelScn1a protein, mouseScn8a protein, mouseSerotoninbreathingrespirationserotoninSUDEP

Identifiers

PMID37160367
PMCPMC10324997
OpenAlexW4375948061

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.